Top 10 articles on HIV prevention from AIDS 2020

Image: Raphael Landovitz (bottom left) presenting results on injectable PrEP at an AIDS 2020 online press conference.

The 23rd International AIDS conference was held virtually in July 2020 and presented some interesting news in HIV prevention. In case you were not able to access the conference, the following ten articles detail some important updates.

The government in Vietnam has endorsed the message that people living with HIV with an undetectable viral load are unable to pass on the virus, known as Undetectable = Untransmittable (U=U). Vietnam is using U=U as the backbone for their strategy to manage HIV. This has resulted in more than 95% people living with HIV in Vietnam having an undetectable viral load and being unable to pass HIV onto others.

Promising research in pre-exposure prophylaxis (PrEP) could mean that tablets are no longer the only choice for how to protect yourself from HIV. A study in Los Angeles proved that injections of cabotegravir every 8 weeks resulted in fewer HIV infections, when compared to oral PrEP.



An umbrella term for people whose gender identity and/or gender expression differs from the sex they were assigned at birth.

Undetectable = Untransmittable (U=U)

U=U stands for Undetectable = Untransmittable. It means that when a person living with HIV is on regular treatment that lowers the amount of virus in their body to undetectable levels, there is zero risk of passing on HIV to their partners. The low level of virus is described as an undetectable viral load. 

drug interaction

A risky combination of drugs, when drug A interferes with the functioning of drug B. Blood levels of the drug may be lowered or raised, potentially interfering with effectiveness or making side-effects worse. Also known as a drug-drug interaction.


A chemical messenger which stimulates or suppresses cell and tissue activity. Hormones control most bodily functions, from simple basic needs like hunger to complex systems like reproduction, and even the emotions and mood.

harm reduction

Harm reduction is a set of practical strategies and ideas aimed at reducing negative consequences associated with drug use (including safer use, managed use and abstinence). It is also a movement for social justice built on a belief in, and respect for, the rights of people who use drugs.

Long-term PrEP studies in San Francisco and Australia showed high levels of PrEP uptake. The data also showed that Black people and women respectively were more likely to discontinue PrEP than other groups in each programme.

Other studies from Australia and the USA showed that PrEP use has decreased during the coronavirus pandemic. This was usually a personal choice rather than because of a lack of access, with many people having less sex during the pandemic. However, researchers noted concerns over the decrease in prescription refills for PrEP in more vulnerable communities.

The lack of equality in HIV prevention was demonstrated in two British studies. In all populations, diagnosis of new cases of HIV are falling. However, the studies found that in certain groups, including Black and ethnic minority communities, new HIV cases are not decreasing as quickly. Furthermore, the use of PrEP was less likely in those with lower socio-economic status.

Multiple African studies have highlighted the benefits of PrEP, including research in Cape Town showing more than a 50% decline in new rates of HIV in women, despite only 25% of women using PrEP in the study. Kenyan and Ugandan research showed that targeted PrEP use in those at high risk decreased HIV incidence by 74%. This is the highest reduction seen in any sub-Saharan African PrEP initiative.

Another example of the benefits of targeted PrEP are community clinics for transgender women in Vietnam. These have led to a substantial increase in enrolment and 98% retention of transgender women on PrEP. Despite having a higher risk of HIV, PrEP uptake had previously been poor amongst trans women. Services were adapted to include information specific to trans women, peer support and hormone level testing.

Patterns of PrEP usage in Africa show that it is common for people to start and stop PrEP rather than taking it without a break. One study in young women from Lesotho stated that a bad interaction with a healthcare provider was the most common reason for stopping PrEP. This was despite 21% of women who stopped PrEP identifying themselves as being at high risk of HIV, compared to only 6% of those that continued.

Research from Tanzania and Ukraine emphasised the importance of harm reduction strategies for HIV prevention. HIV testing and access to sterile injecting equipment significantly reduced the prevalence of HIV.

Click on the links to find out more.