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Disabling CCR5 Could Be Key to a Cure—but at What Cost?

Interfering with this receptor on immune cells could have harmful health consequences.

Published
7 hours ago
From
Poz
Is It Safe to Alter the CCR5 Receptor? And How Will This Influence HIV Cure Studies?

The HIV cure effort suffered a potential setback this week, as researchers reported an association between having two copies of the CCR5-∆32 mutation and shorter survival.

Published
11 June 2019
From
NEJM Journal Watch
UCSF loses contract as Trump administration restricts fetal tissue research

The Trump administration on Wednesday announced major new restrictions in funding of research involving human fetal tissue — a product that many scientists say is irreplaceable in studying certain diseases — in a move that immediately ended a decades-long partnership with UCSF involving HIV research.

Published
07 June 2019
From
San Francisco Chronicle
Fetal Tissue Research Ban Threatens Progress Toward Cure for HIV, Other Life-threatening Diseases

The Department of Health and Human Services’ announcement Wednesday that it will halt funding for research involving the use of human fetal tissue conducted within the National Institutes of Health, and review funding for research at extramural research universities with potential new restrictions, will significantly imperil our most promising strategies to develop a cure for HIV and other life-threatening diseases, while soundly undermining the administration’s stated commitment to ending the HIV epidemic.

Published
07 June 2019
From
HIV Medicine Association
Could gold be the key to making gene therapy for HIV, blood disorders more accessible?

Could gold be the key to making gene therapy for HIV, blood disorders more accessible?  Scientists at Fred Hutchinson Cancer Research Center took a step toward making gene therapy more practical by simplifying the way gene-editing instructions are delivered to cells. Using a gold nanoparticle instead of an inactivated virus, they safely delivered gene-editing tools in lab models of HIV and inherited blood disorders, as reported May 27 in Nature Materials.

Published
28 May 2019
From
Phys.org
Attacking persistent HIV reservoirs via a ‘long noncoding’ RNA

As effective as antiretroviral drugs have been in the treatment of HIV, the virus can still hide out in the body in reservoirs that have proven exceedingly difficult to eradicate. Now researchers at Cornell University have found a new way to attack these HIV reservoirs, and it involves “long noncoding” RNAs (lncRNAs), which don’t produce proteins themselves but instead dial protein-producing genes up or down.

Published
26 March 2019
From
Fierce Biotech
Science Issues Concern About HIV Remission Monkey Study

The journal Science is warning readers that an article it published on a much-hyped potential HIV remission approach didn't include all the facts.

Published
22 March 2019
From
Medscape (requires free registration)
A Path to Curing H.I.V.

The Daily podcast: For only the second time since the start of a global epidemic, a person was reported this month to have been cured of H.I.V., the virus that causes AIDS. Scientists and activists had almost given up on reaching that milestone. Here’s a look at how we got to this point.

Published
21 March 2019
From
New York Times (audio)
Curing HIV just got more complicated. Can CRISPR help?

Antiretroviral (ARV) drugs have turned HIV infection from a death sentence to a chronic condition. In most people the drugs routinely tamp HIV levels so low that standard tests find no virus in blood samples. But inexplicably, in about 10% of infected people HIV remains easily detectable in the blood even though they take their daily pills and are not saddled with drug-resistant mutants of the virus.

Published
18 March 2019
From
Science
Italy's therapeutic AIDS vaccine shows drastic reduction of HIV virus reservoirs: study

Clinical trials of an Italian therapeutic vaccine against AIDS showed a drastic reduction of virus reservoirs in treated patients, Italian researchers said on Wednesday.

Published
14 March 2019
From
Xinhua
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.