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Attacking persistent HIV reservoirs via a ‘long noncoding’ RNA

As effective as antiretroviral drugs have been in the treatment of HIV, the virus can still hide out in the body in reservoirs that have proven exceedingly difficult to eradicate. Now researchers at Cornell University have found a new way to attack these HIV reservoirs, and it involves “long noncoding” RNAs (lncRNAs), which don’t produce proteins themselves but instead dial protein-producing genes up or down.

Published
26 March 2019
From
Fierce Biotech
Science Issues Concern About HIV Remission Monkey Study

The journal Science is warning readers that an article it published on a much-hyped potential HIV remission approach didn't include all the facts.

Published
22 March 2019
From
Medscape (requires free registration)
A Path to Curing H.I.V.

The Daily podcast: For only the second time since the start of a global epidemic, a person was reported this month to have been cured of H.I.V., the virus that causes AIDS. Scientists and activists had almost given up on reaching that milestone. Here’s a look at how we got to this point.

Published
21 March 2019
From
New York Times (audio)
Curing HIV just got more complicated. Can CRISPR help?

Antiretroviral (ARV) drugs have turned HIV infection from a death sentence to a chronic condition. In most people the drugs routinely tamp HIV levels so low that standard tests find no virus in blood samples. But inexplicably, in about 10% of infected people HIV remains easily detectable in the blood even though they take their daily pills and are not saddled with drug-resistant mutants of the virus.

Published
18 March 2019
From
Science
Italy's therapeutic AIDS vaccine shows drastic reduction of HIV virus reservoirs: study

Clinical trials of an Italian therapeutic vaccine against AIDS showed a drastic reduction of virus reservoirs in treated patients, Italian researchers said on Wednesday.

Published
14 March 2019
From
Xinhua
CROI 2019: Will the “Düsseldorf patient” make three — further propelling cure research?

Five years after a stem cell transplant with the same critical factor as those received by the Berlin patient and the London patient, and four months after stopping antiretroviral treatment, a Düsseldorf man remains virally suppressed

Published
12 March 2019
From
Science Speaks
Anthony Fauci: Physicians cured a man of HIV, but that's not our best shot at fighting AIDS

The Berlin and London patients give important insights for HIV researchers, and a cure for HIV is an aspiration we continue to pursue. But the end of the epidemic - the reduction of new HIV infections and HIV-related deaths to very low levels - is within our reach even without a cure.

Published
12 March 2019
From
Sydney Morning Herald
What You Need to Know About the Second Person Likely Cured of HIV

Interview with Richard Jefferys, the Basic Science, Vaccines, and Cure Project Director of Treatment Action Group, about the significance of the second person seemingly cured of HIV, what both community members and journalists should know about this study, and how HIV cure research stories in the mainstream press can create false hope for people living with HIV.

Published
11 March 2019
From
The Body Pro
When Undetectable Is Unachievable: Study Offers Insights into HIV Persistence

Rarely, people living with HIV are unable to maintain an undetectable viral load despite strict adherence to daily ART. New NIAID-funded research suggests that this sometimes can occur when a single cell from the HIV reservoir—the population of long-lived HIV-infected cells that ART cannot eradicate—multiplies to create many identical cells that produce enough virus to be detected by standard viral load tests.

Published
11 March 2019
From
National Institute of Allergy and Infectious Diseases
This is Not A Cure for My H.I.V.

The news about a second person who may be free of the infection is a distraction from the work we need to keep focusing on.

Published
11 March 2019
From
New York Times
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.