High death rate in mpox outbreak in the Democratic Republic of Congo

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The Democratic Republic of the Congo (DRC) is in the midst of an mpox (formerly known as monkeypox) outbreak that has led to nearly 600 deaths, according to the World Health Organization (WHO). Unlike last year’s global outbreak, this one involves a different clade of mpox virus that causes more severe disease. What’s more, sexual transmission of this strain is playing a role for the first time, especially among men who have sex with men.

“These new features of sexual transmission now raise additional concerns over the continuing rapid expansion of the outbreak in the country in a nationally and internationally mobile key population,” according to the WHO report. “The risk of mpox further spreading to neighbouring countries and worldwide appears to be significant.”

The global mpox outbreak that started in May 2022 has declined dramatically, though sporadic clusters are still being reported. As of October 2023, WHO has tallied nearly 92,000 cases in 116 countries, resulting in 167 deaths, not including the DRC outbreak.



The term for the different sub-types of HIV.


The study of the causes of a disease, its distribution within a population, and measures for control and prevention. Epidemiology focuses on groups rather than individuals.


Immunisation is the process whereby a person is made immune or resistant to an infectious disease, typically by the administration of a vaccine. Vaccines stimulate the body’s own immune system to protect the person against subsequent infection or disease.


point-of-care test

A test in which all stages, including reading the result, can be conducted in a doctor’s office or a community setting, without specialised laboratory equipment. Sometimes also described as a rapid test.


An umbrella term for people whose gender identity and/or gender expression differs from the sex they were assigned at birth.

Mpox is an orthopoxvirus closely related to smallpox. It causes lesions on the skin and mucous membranes, sometimes accompanied by flu-like symptoms. Mpox virus has two known types, clade I (endemic in the Congo Basin region), which is more severe, and clade II (endemic in West Africa). Last year’s global outbreak, which involved clade IIb, had a low fatality rate, though it was more deadly among people with AIDS and others with advanced immune suppression.

Prior to the global outbreak, mpox was known as an uncommon disease in western and central Africa, where it largely affected children. It was often associated with contact with wild animals and was not thought to spread easily between people. The epidemiology changed with a 2017 clade II mpox outbreak in Nigeria, in which most of those affected were men and sexual transmission appeared to play a key role—although this largely flew under the radar.

As aidsmap previously reported, the UK Health Security Agency announced the first case in the global outbreak in May 2022: a man who had recently travelled to Nigeria. After that, clade II mpox began to spread among gay men, many of whom reported international travel. Before long, outbreaks emerged in cities in Europe and North and South America. Worldwide, most cases have involved gay, bisexual and other men who have sex with men, many of whom had multiple sex partners and frequented venues and events where sex takes place.

2023 DRC outbreak

So far this year, more than 12,500 suspected cases of clade I mpox – meaning clinically diagnosed but not necessarily confirmed by laboratory testing – have been identified in the DRC, which did not report any clade II mpox cases during the global outbreak.

“The WHO report did not include the HIV status of mpox patients, but the DRC has a high rate of HIV among men who have sex with men.”

In March, a resident of Belgium tested positive for clade I mpox in Kenge, a city in Kwango province, during a visit to the DRC. Exposure likely occurred outside the DRC – he already had symptoms upon arrival and he reported having sex with a man in Europe who had mpox symptoms, according to a report in Emerging Infectious Diseases.

During his travels, the man visited “discretely operating” underground clubs frequented by men who have sex with men, and he reported nine sexual contacts in the DRC (six men and three women). These individuals reported an additional 36 sexual contacts. Ultimately, five people (four men and one woman) tested positive—the first time Clade I mpox virus has been linked to sexual transmission. These five patients received supportive care and pain control on an outpatient basis.

“This event is unusual and highlights the risk that [mpox] clade I could also widely spread among sexual networks, as seen for clade II during the 2022-23 global outbreak,” the WHO authors wrote.

In August, mpox cases were confirmed for the first time in Kinshasa, the capital of the DRC. Four separate events were identified in which people exposed in other provinces travelled to the city, leading to local transmission clusters. Of the 102 suspected cases in Kinshasa, two thirds were among men. At least one person was a health care worker. One individual, who also had tuberculosis, died after contracting mpox in a hospital.

In September, the first mpox case was reported in South Kivu province, involving a young trader who had travelled from another province where clade I mpox is endemic. Epidemiological investigation identified 113 contacts. This outbreak grew to 80 suspected and 34 confirmed cases, including 20 sex workers.

“Our findings highlight historically unrecognized [mpox virus] transmission through sexual contact and indicate the need for increased routine screening in sexual health clinics in mpox-endemic and nonendemic regions,” wrote the authors of the Emerging Infectious Diseases report. “Population movement and previously unreported routes of transmission could exacerbate global distribution of [mpox virus], which could be compounded by the lack of routine diagnostic testing or inadequate access to rapid point-of-care testing. In view of this investigation, epidemiologic and genomic surveillance for [mpox virus], in both endemic and nonendemic regions, should be improved and strengthened.”

High fatality rate

The 12,569 clade I mpox cases reported through 12 November have occurred in 22 out of 26 provinces in the DRC – the largest number of annual cases ever reported. However, due to limited access to diagnostics, only 1106 suspected cases—about 9% – have undergone PCR testing, with 714 testing positive (a 65% positivity rate).

The DRC outbreak has led to 581 deaths, for a case fatality rate of 4.6%. In contrast, the clade II global outbreak had a case fatality rate of about 0.2%. The number of deaths in the DRC this year already far exceeds that of the global outbreak since May 2022. However, as Dr Jeremy Faust noted in an article for MedPage Today, this only includes people who were ill enough to seek medical care. With limited testing available, many more people might have had mild or asymptomatic mpox, suggesting the infection fatality rate is actually substantially lower.

The high death rate is likely attributable in part to clade I mpox, which is known to cause more severe illness. Health status may also be a factor. The WHO report did not include the HIV status of mpox patients, but the DRC has a high rate of HIV among men who have sex with men (estimated at around 7%), and due to the limited availability of care, many people may be unaware of their status and remain untreated.

In the clade II global outbreak, people with advanced HIV were prone to more severe mpox complications and had a high mortality rate (27%), although this is not the case for HIV-positive people with an adequate CD4 cell count. In the United States, most of the 55 people who have died with mpox were Black gay men with AIDS.

To control the clade II outbreak, “three major challenges lie ahead: diagnosis, treatment and vaccination,” according to Dr Jean-Jacques Muyembe-Tamfum, director-general of the DRC’s National Institute for Biomedical Research. While homosexuality is not illegal in the DRC, it is highly stigmatised, which may discourage people with mpox from seeking care.

While the MVA-BN vaccine (sold as Imvanex in Europe and Jynneos in the US) has been widely deployed in several high-income countries, it is still not readily available in Africa outside of research settings. The same is true for the antiviral drug tecovirimat (TPOXX).

“These tools are available and can’t be limited only to wealthy countries,” said Dr Boghuma K. Titanji of Emory University. “I am still able to offer vaccines for mpox at my clinic in Atlanta, although our case numbers have decreased dramatically in recent months. Health care providers in the DRC should be able to do the same for communities there facing a far more deadly outbreak of the disease. It is shameful that this is still a debate just a few months after the global outbreak of mpox, which was an emergency when wealthy western countries were affected. We need to do better.”

What’s more, the Clade I global outbreak shows the potential for mpox to spread beyond endemic countries, especially within sexual networks of highly mobile gay and bisexual men. Although mpox has waned in the United Kingdom, last month the country's Joint Committee on Vaccination and Immunisation made a new recommendation that sexual health clinics should offer mpox vaccination to gay and bisexual men and transgender people at highest risk of exposure to mpox before another outbreak occurs.


World Health Organization. Mpox (monkeypox) - Democratic Republic of the Congo. 23 November 2023.

Kibungu EM et al. Clade I–Associated Mpox Cases Associated with Sexual Contact, the Democratic Republic of the Congo. Emerging Infectious Diseases, published online 28 November 2023 (open access).