Type 2 diabetes and HIV

Image: Andrey_Popov/Shutterstock.com

Key points

  • Changes to your lifestyle can reduce your risk of diabetes.
  • Diabetes requires frequent monitoring and can have serious consequences if left untreated.
  • Rates of diabetes are higher in people living with HIV than in the general population.

When we eat, our body digests food into glucose (blood sugar) which is carried in the bloodstream and enters cells throughout the body where it is used as energy. If you have type 2 diabetes, this process doesn’t work well. Glucose cannot enter the cells that need it and instead builds up in your bloodstream.

A substance called insulin helps glucose to enter cells and keeps glucose at the right level in your blood. People with type 2 diabetes have insulin resistance, which means that the insulin cannot work properly, the pancreas does not produce enough insulin, or both.

Professor Samuel Seidu talks about what diabetes is in Health & Power.

High levels of glucose in your blood make it thick and sticky and can result in damage to the blood vessels in different parts of the body. If your cells don’t get enough glucose, they cannot function properly. Over time, this can lead to serious health problems including heart disease, kidney failure, blindness, and digestive issues. Consistently high levels of glucose can also result in damage to the blood supply to nerves in the hands and the feet. This can cause serious complications in the feet.

Type 2 diabetes requires regular and frequent monitoring of your blood glucose levels. You may need to make significant changes to the food you eat and other lifestyle changes.

This factsheet describes type 2 diabetes, which increasingly affects people living with HIV as they get older. You may also hear about type 1 diabetes (which usually develops during childhood) and gestational diabetes (which can affect pregnant women). Each condition is managed differently.

You might be told that your levels of blood glucose are higher than normal but not high enough for a diagnosis of diabetes. This is sometimes called pre-diabetes or impaired glucose tolerance. It means that you are at increased risk of developing type 2 diabetes, especially if you don’t make changes to your lifestyle.

Your lifestyle and diabetes

Changes to your lifestyle can reduce your risk of diabetes. If you are living with type 2 diabetes, the same lifestyle changes will help keep your blood glucose levels under control.

Lose weight. This is particularly important if you have excess weight around your belly as larger waist sizes are associated with an increased risk of diabetes. You should aim to keep your weight within the ideal range for your height, age and sex. Your doctor, nurse or dietitian can tell you what this range is. Even losing a little weight can make a big difference.

Exercise regularly. You should aim to do at least 150 minutes of moderate aerobic activity every week (for example 30 minutes on five days a week). Moderate activity will raise your heart rate and make you breathe faster and feel warmer. It includes activities like walking fast, dancing, gardening and cycling. It is also recommended that you do some muscle-strengthening exercises (lifting weights or doing exercises that use your own body weight like yoga or Pilates).

You could also make sure you walk at least 10,000 steps every day. You can monitor how many steps you walk using an app on your smartphone or buy a cheap pedometer. Ideas to help achieve 10,000 steps every day include parking your car further away from the shops or getting off the bus two stops early. In bad weather, you could walk inside shopping centres or museums.

Eat a healthy, balanced diet. A Mediterranean-style diet is recommended, with a lot of vegetables, beans and whole grains. Replace red meat with moderate amounts of chicken and fish. Limit foods and drinks that are high in refined sugar. This may be easier if you plan your meal around vegetables rather than meat, rice or pasta.

If you have been diagnosed with type 2 diabetes, you should mostly eat foods with a low glycaemic index, in other words, ones which only raise blood glucose levels slowly. Also you’ll need to keep track of portion sizes of starchy foods (carbohydrates) in order to keep your blood glucose levels in the right range. However, low-carb diets are not recommended without the advice of a dietitian.

Your GP and HIV clinic can help you access support to make these changes. This can include referring you to a dietitian who can help you find a diet that will suit the way you live and the foods you like to eat.

Who is at risk?

People over the age of 40, including people living with HIV, are more likely to develop diabetes.

Genetic factors play a role in type 2 diabetes. If a close family member (parent or sibling) has had diabetes or a related medical problem (like high blood pressure), then the risk of developing diabetes is higher. Also, probably due to genetic factors, people of South Asian, African or Afro-Caribbean descent are at much higher risk of developing type 2 diabetes.

Professor Samuel Seidu talks about the risk factors for diabetes in Health & Power.

Age and genetic factors combine with lifestyle factors. People who are overweight (especially with excess weight around the belly) and people who are physically inactive are more likely to develop diabetes.

Hepatitis C, high blood pressure, high cholesterol and high triglyceride levels are all associated with an increased risk of diabetes.

Some medications can increase glucose levels and may raise the risk of diabetes. These include corticosteroids like prednisolone and hydrocortisone.

Diabetes in people living with HIV

Rates of diabetes are higher in people living with HIV than in the general population. One important reason is that many people living with HIV have some of the risk factors for diabetes mentioned above.

Chronic inflammation (ongoing activation of the immune system) in response to HIV infection may also raise the risk of diabetes. This dysfunctional response of the immune system can harm organs and body systems. HIV treatment and a healthy lifestyle help reduce inflammation but can’t completely eliminate it.

"The first line of treatment is to devise a healthy eating and physical activity plan to help reduce body weight that, if successful, will bring diabetes under control."

Some anti-HIV medications may contribute to diabetes risk. They include older nucleoside reverse transcriptase inhibitors (zidovudine, stavudine and didanosine) and older protease inhibitors (indinavir and lopinavir). These drugs are not generally used today but you may have taken them in the past.

Some newer treatments including integrase inhibitors (dolutegravir and bictegravir, raltegravir and elvitegravir) have been associated with weight gain, although the reasons for this remain unclear. It’s generally the case that weight gain increases the risk of developing diabetes, but it is not yet clear if the weight gain linked with integrase inhibitors does so.

Overall, integrase inhibitors are well tolerated with few side effects for most people and they may help you suppress your viral load more quickly than other HIV medication. You can still reduce your risk of diabetes by making healthy changes to your lifestyle, including diet and exercise. If you do feel you are gaining excessive weight on your HIV medicines you should discuss this with your HIV clinician.


Many people develop type 2 diabetes without noticing it. When symptoms do occur, they can include increased thirst, frequent urination, increased hunger, weight loss, tiredness, blurred vision, slow-healing sores or frequent infections, and areas of darkened skin.

Diabetes can also contribute to sexual problems including problems getting or maintaining an erection, vaginal dryness and other issues.

In the long term, uncontrolled diabetes raises the risk of heart diseasestroke, liver disease and kidney disease. Complications of diabetes can affect the skin, eyes, and nerves in the legs, feet and hands.

Diagnosis and monitoring

If you are aged 40 or over, your HIV clinic should run a blood test once a year to check the level of glucose in your blood. This test is called haemoglobin A1c and gives an average of your glucose levels over the previous 12 weeks. It will indicate whether your blood glucose level is normal, higher than normal, or at a level which shows you have diabetes. Results for haemoglobin A1c may be a little different in people taking HIV treatment than in other people – your doctor should take this into account when interpreting the results.

Another diagnostic test for diabetes is the fasting glucose test. This is a simple blood test and will require you to fast (no food and no drinks other than water) for eight to ten hours beforehand.

If you are diagnosed with diabetes, the situation will be monitored with the haemoglobin A1c test. You have these checks every three months when newly diagnosed, then every six months once you are stable.

If you are taking diabetes treatment, you may need to monitor your glucose levels on a daily basis. This will help you monitor your health and see if your treatment is working. Your doctor may ask you to do daily blood glucose tests at home or provide you with a flash or continuous glucose monitor. Daily blood glucose tests involve pricking your finger and applying a small amount of blood to a hand-held meter provided by the NHS. Flash or continuous glucose monitors are small devices that you wear under your skin, usually on your arm or belly.

Your blood pressure, cholesterol and triglycerides should be measured regularly as part of your HIV monitoring. This is also important for monitoring diabetes.

Treatment and management

The first line of treatment is to devise a healthy eating and physical activity plan to help reduce body weight that, if successful, will bring diabetes under control. In some people, losing weight and maintaining a healthy diet can cause their diabetes to go into remission. This means their glucose levels remain at a normal range without the need for diabetes medication.

If this approach does not make enough of a difference, medication may be used as well. You may be given tablets that either encourage the body to produce more insulin or make the existing insulin supply work better. The standard choice is a tablet called metformin, although other medication is available. Your doctor may recommend that you take a combination of different medications.



A group of diseases characterized by high levels of blood sugar (glucose). Type 1 diabetes occurs when the body fails to produce insulin, which is a hormone that regulates blood sugar. Type 2 diabetes occurs when the body either does not produce enough insulin or does not use insulin normally (insulin resistance). Common symptoms of diabetes include frequent urination, unusual thirst and extreme hunger. Some antiretroviral drugs may increase the risk of type 2 diabetes.


A simple form of sugar found in the bloodstream. All sugars and starches are converted into glucose before they are absorbed. Cells use glucose as a source of energy. People with a constant high glucose level might have a disease called diabetes.


A hormone produced by the pancreas that helps regulate the amount of sugar (glucose) in the blood.


An association means that there is a statistical relationship between two variables. For example, when A increases, B increases. An association means that the two variables change together, but it doesn't necessarily mean that A causes B. The relationship isn't necessarily causal.

integrase inhibitors (INI, INSTI)

A class of antiretroviral drugs. Integrase strand transfer inhibitors (INSTIs) block integrase, which is an HIV enzyme that the virus uses to insert its genetic material into a cell that it has infected. Blocking integrase prevents HIV from replicating.

Some people with type 2 diabetes also need daily injections of insulin, but this is not the case for everyone.

Healthcare professionals involved in managing diabetes include GPs, specialist nurses and specialist dietitians. A doctor specialising in diabetes may be a diabetologist or an endocrinologist (a doctor who treats disorders of the glands and hormones, including diabetes).

It’s best for the doctors treating your diabetes and your HIV to liaise about your health care. For this to happen, you need to give your permission for them to share your medical information. You can also ask your doctors and pharmacists to check that there are no drug-drug interactions between your treatments for diabetes and HIV.

Other sources of information

For more information, you may find the website of Diabetes UK helpful: www.diabetes.org.uk. You can also contact their helpline team on 0845 601 02 09.

The NHS Healthier You Diabetes Prevention Programme is aimed at people with pre-diabetes. If you are eligible, you can access this programme via your GP or through self-referral at preventing-diabetes.co.uk

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Thanks to Dr Tristan Barber for his advice.