Not having enough food linked with lower chances of sustained viral suppression for ART-treated breastfeeding mothers in Uganda

Not having enough food is associated with poorer chances of achieving a sustained viral suppression among antiretroviral-treated breastfeeding women in Uganda, investigators report in the online edition of the Journal of Acquired Immune Deficiency Syndromes.

“In this cohort of HIV-infected women in rural Uganda who initiated ART during pregnancy, food insufficiency [FI] [defined as inadequate quantities of food available] was highly prevalent,” comment the authors. “FI was associated with 62% lower odds of achieving and sustaining viral suppression during pregnancy and breastfeeding.”

This is the first study to show an association between food insecurity and poor viral suppression among pregnant and breastfeeding women, a period “when viral suppression has implications both for preserving maternal health and reducing the risk of perinatal transmission.”

Glossary

virological suppression

Halting of the function or replication of a virus. In HIV, optimal viral suppression is measured as the reduction of viral load (HIV RNA) to undetectable levels and is the goal of antiretroviral therapy.

hypothesis

A tentative explanation for an observation, phenomenon, or scientific problem. The purpose of a research study is to test whether the hypothesis is true or not.

perinatal

The period of time shortly before and after birth.

naïve

In HIV, an individual who is ‘treatment naïve’ has never taken anti-HIV treatment before.

exclusive breastfeeding

Feeding an infant only breast milk, with no other liquids or solids, for the first six months of life.

Previous research has shown a relationship between food insecurity (uncertain access to safe and nutritious food) and lower rates of viral suppression among ART-treated patients in the US and Uganda.

Pregnant and breastfeeding women may be especially vulnerable to food insecurity and insufficiency. Moreover, food insecurity during pregnancy and breastfeeding has been associated with reduced blood levels of antiretrovirals, pre-term delivery and low birth weight infants. Food insecurity may also be a barrier to exclusive breastfeeding.

ART is now recommended for all pregnant and breastfeeding HIV-positive women. Investigators therefore wanted to establish if food insufficiency was associated with lower chances of sustained viral suppression among ART-treated HIV-positive women in the year after giving birth.

Participants were recruited from the PROMOTE-Pregnant Women and Infants study, which was designed to test the hypothesis that therapy with lopinavir/ritonavir would reduce the prevalence of placental malaria. HIV-positive ART-naïve women were recruited between weeks 12 and 28 of gestation.

Women under observation between September 2011 and February 2012 were included in the food insecurity sub-study. Viral load was measured eight weeks after delivery and then at regular intervals through to week 48. Patients who maintained a viral load below 400 copies/ml were regarded as having sustained viral suppression.

Food insufficiency was assessed using the Household Hunger Scale. Participants were asked how often: there was no food to eat in their house; they went to bed at night hungry; and went the whole day and night without eating. Responses were ranked on a scale of 0 (never) to 6 (often).

A total of 171 women were included in the analysis. Three-quarters reported food insufficiency and for 9% this was severe.

At 24 weeks postpartum, almost all the women were breastfeeding. Women with sufficient food were more likely than women with food insufficiency to report exclusive breastfeeding (81% vs. 68%). At 48 weeks, 92% of food insufficient women and 95% of food sufficient participants reported partial breastfeeding. Two infants acquired HIV; both had mothers who reported food insufficiency.

Similar proportions of food-sufficient and food-insufficient women achieved viral suppression at some point during follow-up (90% vs. 92.5%). However, women with enough food were more likely than women reporting insufficiency to have sustained viral suppression (79% vs. 60%, p = 0.03).

In an analysis that controlled for potential confounders, food insufficiency was associated with significantly lower chances of sustained viral suppression (aOR = 0.38; 95% CI, 0.16-0.91, p = 0.03). Other risk factors were higher pre-therapy viral load (p < 0.01) and treatment with lopinavir/ritonavir vs. efavirenz (p = 0.04).

“Food insecurity may be an important and modifiable determinant of adverse virologic outcomes among pregnant and lactating women,” conclude the authors. “Interventions to reduce food insufficiency may result in improved outcomes among HIV-infected women and their children, and merit further attention from the research and programmatic communities.”

References

Koss CA et al. Food insufficiency is associated with lack of sustained viral suppression among HIV-infected pregnant and breastfeeding women. J Acquir Immune Defic Syndr. Online edition, DOI: 10.1097/QAI.0000000000000860 (2015).