Other blood tests

Every time you visit your clinic for a check-up you’ll have some blood tests. As well as being used to monitor your CD4 cell count and viral load, these will help your clinic monitor your general health. HIV infection and HIV treatment can sometimes cause changes in your body, affecting aspects of your health such as your liver or kidney function, your blood fats (lipids – cholesterol and triglycerides), and your bone health.

Monitoring these sorts of changes is important, as signs that you are developing some health problems, or are at high risk of them, can be a reason to start or change treatment. Your doctor will tell you if they think this is the case.

If you’re taking HIV treatment, monitoring tests can also give an indication of whether you’re developing side-effects. 

Some tests can also tell if you have certain infections.

A lot of the tests discussed below are routine – that means that you’ll have them every time you have blood tests at your clinic or on a regular basis, such as once a year. Some others you’ll only have if they are needed.

It is generally best to look at the trend in results over time rather than focusing too much on one result. Your doctor will discuss the results of your blood tests with you to help decide the best course of treatment. Your doctor may not always discuss the results of tests if they are normal, but you can ask for more information.

The tests described below have been grouped together according to what they are looking at.

We haven’t provided information on the normal ranges of such results. This is because these can differ depending on all sorts of factors, including your age, your gender, and even the measurements used by the testing laboratory.

Blood chemistry

A full blood count will include:

  • a red blood cell count. This measures haemoglobin, the substance that allows your red blood cells to carry oxygen around your body. If your haemoglobin is too low you are said to have anaemia. Haemoglobin levels are often a bit lower in people with HIV and anaemia is more common than in the general population.
  • a platelet count. These cells clot the blood. People with HIV often have fewer platelets than average, although this generally doesn’t cause problems.
  • a white blood cell count. This is a measure of the total number of white blood cells. These cells are part of the immune system and defend against infections. People with HIV often have slightly lower levels but, again, this isn’t usually a problem.

You should have a full blood count when you are first diagnosed with HIV and again when you start HIV treatment; generally, you will also have a full blood count every year. You may have one more often if you are unwell or if you are taking zidovudine (AZT, Retrovir).

Blood fats or lipids

Glossary

cholesterol

A waxy substance, mostly made by the body and used to produce steroid hormones. High levels can be associated with atherosclerosis. There are two main types of cholesterol: low-density lipoprotein (LDL) or ‘bad’ cholesterol (which may put people at risk for heart disease and other serious conditions), and high-density lipoprotein (HDL) or ‘good’ cholesterol (which helps get rid of LDL).

lipid

Fat or fat-like substances found in the blood and body tissues. Lipids serve as building blocks for cells and as a source of energy for the body. Cholesterol and triglycerides are types of lipids.

triglycerides

The basic 'building blocks' from which fats are formed.

 

resistance

A drug-resistant HIV strain is one which is less susceptible to the effects of one or more anti-HIV drugs because of an accumulation of HIV mutations in its genotype. Resistance can be the result of a poor adherence to treatment or of transmission of an already resistant virus.

lactate

Another name for lactic acid.

Cholesterol and triglycerides are blood fats, often called lipids. There are two types of cholesterol – low-density lipoprotein (LDL) cholesterol (sometimes called ‘bad cholesterol’) and high-density lipoprotein (HDL) cholesterol (sometimes called ‘good cholesterol’). HIV is linked with increased levels of triglycerides and LDL cholesterol and lower levels of HDL cholesterol, and some anti-HIV drugs can affect lipid levels.

High lipids have been linked to an increased risk of cardiovascular disease (illnesses such as heart disease and stroke). Having low levels of HDL cholesterol has also been linked to cardiovascular problems and can be a marker of a risk of other serious illnesses as well.

You should have your lipids measured when you are first diagnosed with HIV. If you are over the age of 40, if you smoke or if your body mass index (BMI) is over 30, then they will be checked every year. The tests include:

  • total cholesterol. This is a measure of the total level of cholesterol in your blood.
  • levels of LDL cholesterol.
  • levels of HDL cholesterol.
  • levels of triglycerides.

Your doctor will ask you to come for a blood test in the morning and they will explain that you should not eat anything before having this test, as the test needs to be done after you have fasted.

Your doctor will look at your lipid levels in relation to whether there are other factors that might put you at higher risk of cardiovascular disease, such as your age, smoking, having a family history of heart disease, or having high blood pressure or diabetes.

If your cholesterol or triglyceride levels are too high, your doctor will talk to you about how you can lower them. This is likely to start with lifestyle changes, such as changing your eating habits and losing weight, increasing exercise or stopping smoking. But there are also drugs that lower cholesterol (statins) and triglycerides (fibrates) as well.

The results of your lipid tests can also help you and your doctor choose the most suitable anti-HIV drugs for you.

If you have symptoms of certain conditions, blood samples may also be measured to check levels of the enzymes amylase, creatine kinase, lactate dehydrogenase and lactate. Abnormal levels of amylase can be a warning sign that you are at risk of the very serious side-effect pancreatitis. This can be caused by some anti-HIV drugs in the nucleoside reverse transcriptase inhibitor (NRTI) class. Abnormal levels of lactate can be a sign of the rare, but very serious, side-effect lactic acidosis. This can also be caused by NRTI drugs.

Resistance tests

When you are first diagnosed with HIV, you should have a resistance test. The test you have at this time provides information on any resistance to certain drugs present in the strain of HIV you have.

You will have a resistance test before you start HIV treatment if you didn’t have one when you were first diagnosed, or if there are signs that you might have been exposed to another strain of HIV (sometimes called reinfection or superinfection). This could include a sudden rise in your viral load or a sudden fall in your CD4 cell count.

You will also have a resistance test if you need to change your anti-HIV drugs because you have developed a detectable viral load again.

These are blood tests that can help you and your doctor decide which anti-HIV drugs will work best for you.

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