US emergency department testing finds a lot of people with new – and returning – HIV infections

Testing programmes highlight the continuing problem of people dropping out of care
Image: Chompoo Suriyo/Shutterstock.com

Two poster presentations at last month’s Conference on Retroviruses and Opportunistic Infections (CROI 2020) from southern California show that the routine testing of people who present to hospital emergency departments is continuing to find significant numbers of previously undiagnosed people with HIV.

However, it is uncovering an even greater number of people who have already been diagnosed but have been lost to care – and the majority of those are lost again after being tested in the emergency department (ED).

Only 60% of those who were newly diagnosed at a large hospital in Los Angeles were linked to care, and less than half of the ‘re-diagnosed’ patients were re-linked to care. Furthermore only half of those who were re-linked to care were still attending six to nine months later.

Glossary

erectile dysfunction (ED)

A man's inability to have or maintain an erection, also known as ED or impotence.

retention in care

A patient’s regular and ongoing engagement with medical care at a health care facility. 

opportunistic infection (OI)

An infection that occurs more frequently or is more severe in people with weakened immune systems, such as people with low CD4 counts, than in people with healthy immune systems. Opportunistic infections common in people with advanced HIV disease include Pneumocystis jiroveci pneumonia; Kaposi sarcoma; cryptosporidiosis; histoplasmosis; other parasitic, viral, and fungal infections; and some types of cancer. 

acute infection

The very first few weeks of infection, until the body has created antibodies against the infection. During acute HIV infection, HIV is highly infectious because the virus is multiplying at a very rapid rate. The symptoms of acute HIV infection can include fever, rash, chills, headache, fatigue, nausea, diarrhoea, sore throat, night sweats, appetite loss, mouth ulcers, swollen lymph nodes, muscle and joint aches – all of them symptoms of an acute inflammation (immune reaction).

linkage to care

Refers to an individual’s entry into specialist HIV care after being diagnosed with HIV. 

At another hospital in San Diego, slightly more than half of the re-diagnosed were initially linked to care but, again, not many more than half of those were still in care six months later. Methamphetamine users were significantly more likely to drop out of care.

Los Angeles

In the first study, the Emergency Department of the Los Angeles County + University of Southern California Medical Center instituted a routine offer of HIV testing to all ED attendees who needed any lab test. This is the largest ED in the western US; it sees 170,000 patients a year and 50% of Los Angeles County’s people with HIV are within its catchment area.

Between 2011 and January 2020, 119,902 tests had been performed. Of those tested, 62% were men, 61% defined as Hispanic, 16% were black, 10% white, 40% were over 50 and 20% were 30 or under.  

There were 2612 positive results – 2.2%, or one in 46 tests. However 1988 of these were in people already known to have HIV who were ‘re-diagnosed’ (76%). The other 624 (0.52% or one in 192 tests) represented new diagnoses. Of these, 62 had acute HIV infection.

Nearly 60% of the newly diagnosed (366 of the 624 or 58.6 %) were successfully linked to care. Of the re-diagnosed, success in linking them back into the health system was dramatically improved after the ED itself started offering immediate HIV therapy and HIV care in October 2015. Before this, re-linked patients were referred to primary care, with abysmal results – only 14 out of 219 (6%) returned to regular HIV care. After HIV care was started at the ED itself, 109 out of 212 (51%) were successfully re-linked to care.

However only 39% of these 109 patients attended for a second follow-up appointment within the stipulated time of 60 days, and only 48% ever did. These 52 patients represented just a quarter (24.5%) of patients who were re-diagnosed.

San Diego

The second study examined rates of linkage and retention in care in a universal opt-out HIV screening programme at the University of California San Diego hospital emergency departments.

Although the CROI poster does not specify how many tests were done altogether or what proportion were positive, a previous paper about the programme shows that in its first 15 months, between July 2017 and October 2018, 12,575 test results were obtained of which 81 were positive. This proportion of 0.6% (one in 155 patients) is lower than the Los Angeles figure partly because people were specifically asked if they already knew they had HIV and were not tested if they did. Even so, more than half the test results at this point turned out to be people who already had a positive test recorded.

By the beginning of 2020, 139 positive test results had been recorded. Of these, 47 (25%) were new diagnoses, while the other 92 were people already known to have HIV who had not attended for care for over a year. Forty of the newly-diagnosed patients (85%) were linked to care, but only 48 (52%) of the re-diagnosed were.

At six months, 70% of the newly diagnosed and 54% of the re-diagnosed, who had been linked to care were still in care. This means that nearly 60% of all the newly-diagnosed people were still in care six months after being given their test result – but only 28% of all the re-diagnosed were.

The only characteristic statistically associated with being lost to care was methamphetamine (users were 20% more likely to drop out of care), though patients who were young, black, gay and with a history of injection drug use, psychiatric illness or imprisonment were all somewhat more likely to drop out.

The researchers called for better and more continuous case management of patients, especially of methamphetamine users, in order to achieve higher rates of retention in care.

References

Jacobson K et al. Experience from the largest western US emergency department on ending the epidemic. Conference on Retroviruses and Opportunistic Infections, abstract 1139, March 2020.

Read the abstract on the conference website.

See poster here.

Kushagra M et al. HIV screening in emergency departments: linkage works, but what about retention? Conference on Retroviruses and Opportunistic Infections, abstract 1138, March 2020.

Read the abstract on the conference website.

See poster here.