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Integrase inhibitors

Raltegravir

Names: Raltegravir, Isentress 

Dose: One pink 400mg tablet twice daily. 

Tips on taking it: Take with or without food. 

Important warning: An allergic (hypersensitivity) reaction has been reported in some people using raltegravir. See your HIV clinic immediately (or A&E if out of hours) if you develop a rash together with any of these symptoms: fever; feeling generally unwell or extremely tired; muscle or joint ache; blistering of the skin; mouth ulcers; swelling of the eye, lips, mouth or face; breathing difficulties; yellowing of the skin or eyes; dark urine; pale stools; or pain, aching or sensitivity on the right-hand side of the body, below the ribs.

Common side-effects: Headache, insomnia. 

Rare side-effects: Severe rash, hypersensitivity reaction, extreme thirst (polydipsia).

Key drug interactions: If you are prescribed the TB drug rifampicin, your dose of raltegravir may be increased to 800mg (two tablets) twice daily, as rifampicin can reduce drug levels of raltegravir.

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.