Darunavir/ritonavir & lamivudine matches triple-drug therapy

Jose Arribas speaking at HIV Glasgow. Image credit: HIV Drug Therapy Glasgow 2016

Simplifying antiretroviral therapy to a two-drug combination of lamivudine plus the protease inhibitor darunavir (Prezista) boosted by ritonavir is just as effective as a three-drug regimen in people with suppressed viral load, Spanish investigators reported at the International Congress on Drug Therapy in HIV infection (HIV Glasgow) last week in Glasgow.

Simplifying antiretroviral therapy so that a boosted protease inhibitor or an integrase inhibitor is taken with lamivudine holds several attractions:

  • The simplified regimen may reduce the risk of toxicities potentially associated with use of a second nucleoside or nucleotide analogue: cardiovascular disease in the case of abacavir, and kidney injury or bone loss in the case of tenofovir. Lamivudine has few side-effects and is well tolerated by the vast majority of people.

  • Lamivudine does not interact with drugs used to treat other conditions, reducing the potential for problematic drug interactions between an antiretroviral regimen and other medications, which is especially important in older people with HIV.

  • The simplified regimen is less costly because lamivudine is available in a cheap generic formulation.

  • Virologic rebound after failure of the simplified regimen will not result in cross-resistance to tenofovir, so preserving this drug as a future option. Rebounding virus may also remain sensitive to abacavir, although this depends on previous treatment history.

Pilot studies presented at previous conferences have shown that regimens combining a boosted protease inhibitor (lopinavir/ritonavir) or an integrase inhibitor (dolutegravir) with lamivudine are just as effective as three-drug regimens in previously untreated people.

Glossary

boosting agent

Booster drugs are used to ‘boost’ the effects of protease inhibitors and some other antiretrovirals. Adding a small dose of a booster drug to an antiretroviral makes the liver break down the primary drug more slowly, which means that it stays in the body for longer times or at higher levels. Without the boosting agent, the prescribed dose of the primary drug would be ineffective.

cholesterol

A waxy substance, mostly made by the body and used to produce steroid hormones. High levels can be associated with atherosclerosis. There are two main types of cholesterol: low-density lipoprotein (LDL) or ‘bad’ cholesterol (which may put people at risk for heart disease and other serious conditions), and high-density lipoprotein (HDL) or ‘good’ cholesterol (which helps get rid of LDL).

second-line treatment

The second preferred therapy for a particular condition, used after first-line treatment fails or if a person cannot tolerate first-line drugs.

integrase

HIV enzyme that the virus uses to insert its genetic material into a cell that it has infected.

cardiovascular

Relating to the heart and blood vessels.

Studies presented earlier in the week at HIV Glasgow showed that simplified maintenance regimens in virally suppressed patients were non-inferior to three-drug treatment, both in those without any history of virologic failure and in those already taking second-line treatment.

Previous attempts to simplify therapy using monotherapy with a single boosted protease inhibitor have shown that approach to be less durable than three-drug treatment.

The DUAL study

The DUAL study, conducted in Spain, tested simplification of a regimen containing darunavir (Prezista)/ritonavir, the only recommended boosted protease inhibitor option in European and US guidelines.

The DUAL study randomised 249 people with undetectable viral load on a regimen of darunavir/ritonavir plus either tenofovir/emtricitabine or abacavir/lamivudine either to continue taking their existing regimen or to switch to a simplified regimen of darunavir/ritonavir plus lamivudine. All regimens were dosed once daily.

The study recruited people with no evidence of resistance to darunavir or lamivudine, who had fully suppressed viral load for at least six months on a regimen of darunavir/ritonavir plus either abacavir/lamivudine or tenofovir/emtricitabine.

Three-quarters of participants (75%) were taking tenofovir/emtricitabine and 25% were taking abacavir/lamivudine at randomisation.

The study population was 83% male, 85% Caucasian and 51% men who have sex with men, 27% heterosexual and 15% people who inject drugs. Participants had been on treatment with a fully suppressed viral load for a median of 100 weeks and the median current CD4 cell count was 589 cells/mm3 at the time of randomisation.

After 48 weeks there was no significant difference in the proportion of participants in each study arm with undetectable viral load (< 50 copies/ml), either in the entire study population or if those who stopped assigned treatment for reasons other than virologic failure were excluded.

Eighty-nine per cent of those on the simplified regimen had viral load < 50 copies/ml at week 48, compared to 93% of the triple-drug regimen group by intent-to-treat, missing equals failure analysis. More participants in the two-drug arm had missing data at week 48 but fully suppressed viral load at last clinic visit (5 vs 2%).

Single viral load blips were somewhat more frequent in those receiving a triple-drug regimen (13.2 vs 8.9%) but this difference was not statistically significant. 4.5% of those receiving the two-drug regimen had two viral load blips compared to 2.6% of the triple-drug group.

Resistance testing of individuals who experienced virologic rebound was possible in five cases where viral load rose above 400 copies/ml. Genotype failed in two of five cases. Resistance to darunavir was detectable in one particpant who had been taking a triple-drug regimen but experienced virologic rebound to 447,557 copies/ml.

There was no significant difference in serious adverse events between dual and triple-drug study arms (4.8 vs 4.9%) or in study drug discontinuation due to adverse events (0.8 vs 1.6%).

No significant improvement in kidney function was observed in those who switched to the simplified regimen, nor in total cholesterol/HDL cholesterol ratio.

Presenting the results, Prof. José Arribas of Hospital La Paz, Madrid, said that results of four randomised trials of simplification of boosted protease inhibitor and lamivudine presented a good opportunity for a meta-analysis to inform future treatment guidelines, although some might wish to see evidence of longer-term durability of two-drug regimens.

References

Pulido F et al. Non-inferiority of dual-therapy (DT) with darunavir/ritonavir (DRV/r) plus 3TC versus triple-therapy (TT) with DRV/r plus TDF/FTC or ABC/3TC for maintenance of viral suppression: 48-week results of the DUAL-GESIDA 8014 trial. Journal of the International AIDS Society 2016, 19 (Suppl 7), abstract O331.