Are you taking ddI EC capsules?
(also known as didanosine enteric coated capsules or Videx EC)
If so, it is important that you read this notice!
Which form of ddI are we talking about?
ddI EC is the new capsule form of ddI (NOT the big chalky tablet) which is currently unlicensed in the UK, but due to be launched at the end of September.
Why have we produced this leaflet?
You may have read in Positive Nation that some questions have recently been raised about exactly how long a gap should be left between food and ddI EC. This information is to help clarify the situation.
What is the problem?
The manufacturers have been asked to do some extra studies to confirm exactly how soon after taking the ddI it is safe to eat or drink. As soon as we have any new information we will pass it on to you.
What should I do if I am taking ddI EC?
- Carry on taking all your antiretroviral medicines. ddI EC is still a safe and effective medicine – this is about how best to take it.
- The new recommendation is to take the ddI EC at least 2 hours after food, preferably before bedtime, or as best suits your lifestyle.
- This new information means that ddI EC is taken in a different way from the tablet and suspension formulations. These preparations should still be taken at least 30 minutes before food and at least 2 hours after food.
Until further studies have been done, the company cannot give a precise recommendation about how long a gap must be left after taking the ddI EC and before eating. This is why they are recommending that it is taken at bedtime, at least 2 hours after food, and not to eat again until the morning. However, based on what is known about ddI itself and also about the way that drugs are absorbed into the body, it is reasonable to assume that leaving a gap of at least 2 hours after the ddI EC before eating would be safe.
In other words, you should not eat or drink (except for water) for at least 2 hours before and at least 2 hours after taking your ddI EC.
It is very important that you follow the administration recommendations according to the type of ddI that you are now taking.
What if this new way of taking ddI EC is inconvenient or I have questions or concerns?
- As a result of this information some people may wish to change the time of day that they take their ddI EC (e.g. to bedtime).
- Some people may wish to change to the ddI 200mg tablets (for which the instructions remain unchanged) until the company has further clarified the situation.
- Some people may have questions about the best time for them to take their ddI EC and how it might fit in with their other medicines.
- If any of these apply to you, or if you have any other questions, concerns or worries in relation to your medication, please contact your HIV pharmacist or doctor.
We are sorry for any concern or inconvenience that this change may cause.