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CRISPR Eradicates Latent HIV-1, Offering Hope of "Functional Cures"

Scientists in Japan have used CRISPR-Cas9 technology to stop human immunodeficiency virus type 1 (HIV-1) replication in latently infected T cells that can’t be controlled using existing drug treatments. The gene-editing approach effectively disrupts two regulatory HIV-1 genes, tat and rev, which are essential for viral replication.

Published
22 May 2018
From
Genetic Engineering & Biotechnology News
Discovery of how HIV hedges its bets opens the door to new therapies

HIV covers its bases in a volatile environment by generating both active and dormant infections. But if the virus is randomly switching between these two fates, how does it ever commit to remaining in one state? Weinberger's laboratory has now answered this longstanding question. Researchers may now be able to continually force HIV back into latency by exploiting the virus's splicing circuit and achieve the "lock and block" therapy.

Published
11 May 2018
From
Eurekalert Medicine & Health
Gene editing holds promise for shrinking HIV ‘reservoir’

Study mimicking Timothy Ray Brown’s HIV-resistant mutation led to fewer latently infected cells — a key step toward driving the virus into remission without the need for antivirals

Published
27 April 2018
From
Fred Hutch
Top HIV cure research team refutes major recent results on how to identify HIV persistence

An international team focused on HIV cure research spearheaded by The Wistar Institute in collaboration with the University of Pennsylvania and Vall d'Hebron Research Institute (VHIR) in Barcelona, Spain, established that the CD32 molecule is not a preferential biomarker to identify HIV silent reservoirs within the immune system of patients undergoing antiretroviral therapy (ART), as proposed by a recent landmark study.

Published
19 April 2018
From
Medical Xpress
Gene Regulation May Overpower Hidden HIV Reserves

New research published in The Journal of Clinical Investigation suggests that an epigenetic mechanism that controls gene expression may draw HIV out of hiding and make it vulnerable to ART.

Published
16 March 2018
From
Specialty Pharmacy Times
Very early treatment in children limits the HIV reservoir

Very early HIV treatment in infants is feasible and safe and leads to a small reservoir of infected cells, two studies from Botswana and Thailand

Published
13 March 2018
By
Keith Alcorn
Scientists Find No Signs That Well-Treated HIV Replicates in Lymph Nodes

A research team has found no evidence of ongoing HIV replication in the lymph nodes among individuals receiving fully suppressive antiretroviral (ARV) treatment for the virus. This finding stands in sharp contrast to the conclusions of a 2016 study out of Northwestern University, published in Nature, that indicated that even in the face of ARV treatment, HIV replicates in the lymph nodes, thus helping to replenish the viral reservoir.

Published
06 March 2018
From
Poz
Experimental antibody plus TLR7 agonist maintains viral suppression in monkeys

Treatment with a broadly neutralising antibody plus an immune-stimulating drug led to long-term viral remission after interrupting antiretroviral therapy in a monkey study, according to data presented at

Published
05 March 2018
By
Liz Highleyman
Case Western Reserve and Sangamo Therapeutics Announce $11 Million NIH Grant for Study of Gene-Edited T Cells for Viral Eradication of HIV

The grant will fund a clinical trial to test the hypothesis that treating patients with their own gene-edited T cells may lead to a sustained increase in T cell counts and eradication of latent HIV reservoirs.

Published
07 February 2018
From
Sangamo press release
What does an HIV cure mean to you?

We did a study to better understand the meanings of HIV cure among people living with HIV. This is critical to reconcile what would be clinically feasible with what would be meaningful for people living with HIV.

Published
06 February 2018
From
Positively Aware
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.