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2000-Fold Drop in Latent Reservoir Needed for 1 Year Without ART

About a 2000-fold reduction in the HIV reservoir in resting CD4 cells may be needed to let most people stop antiretroviral therapy (ART) for a single year without rebound, according to results of a modeling study. Predicted large variations in rebound times after ART stops mean close monitoring will be required for this strategy.

Published
11 hours ago
From
International AIDS Society
How HIV co-opts gut bacteria to pose as a familiar infection

One of the most effective methods used by HIV to evade control is to hide from the immune system. B-cells are crucial for controlling new infections, producing specific antibodies to attack it, which coat the surface of infected cells and tag them for destruction. But according to a study from Duke Medicine, published in Cell Host & Microbe, when HIV enters and begins replicating in the gut, the reaction of B cells is ineffective because the virus is able to pose as a “good” bacterium. Its gp41 surface protein - which is displayed on the surface of infected cells - looks like surface proteins on the cells of friendly gut bacteria.

Published
11 hours ago
From
The Conversation UK
'Shock and kill' approach cures mice of HIV in world first

A combination of four drugs can flush out HIV-infected cells from hidden reservoirs in the body and kill them with a boost to the immune system, according to research published in the journal Cell today.

Published
18 August 2014
From
The Conversation
AIDS 2014: Disappointing HIV Cure News Leads to New Questions

The fourth IAS Towards an HIV Cure symposium -- an initiative of the International AIDS Society -- took place July 19-20, prior to the 20th International AIDS Conference in Melbourne.

Published
15 August 2014
From
HIVandhepatitis.com
Drugs that flush out HIV may impair killer T cells, possibly hindering HIV eradication

Histone deacetylase (HDAC) inhibitors have shown promise in 'flushing out' HIV from latently infected cells, potentially exposing the reservoirs available for elimination by cytotoxic T lymphocytes (CTL), also called killer T cells. However, findings now suggest that treatment with HDAC inhibitors might suppress CTL activity and therefore compromise the 'kill' part of a two-pronged 'flush-and-kill' HIV eradication strategy.

Published
15 August 2014
From
Science Daily
Latest HIV purge claims prompt calls for more caution

HIV has been undetectable for more than three years in the blood of two Australian bone-marrow recipients. But recent relapses of other patients who had no detectable virus have dampened optimism about how long the effects last before the virus bounces back.

Published
22 July 2014
From
New Scientist
Novel techniques probed in cure research

Two presentations at the 20th International AIDS Conference (AIDS 2014) in Melbourne described new pathways being explored in the search for either a permanent cure for HIV

Published
22 July 2014
By
Gus Cairns
Romidepsin activates latent HIV, but does not decrease viral reservoir

The HDAC inhibitor romidepsin was able to awaken latent HIV in resting T-cells, causing it to start producing new virus, but this was not associated with a

Published
22 July 2014
By
Liz Highleyman
Reappearance of HIV in "Mississippi Baby" poses questions for early treatment

The 20th International AIDS Conference (AIDS 2014) heard yesterday that the reappearance of HIV in a girl now aged four, who maintained an undetectable viral load

Published
22 July 2014
By
Gus Cairns
AIDS 2014: Researchers discuss progress towards an HIV cure

Progress along the multi-pronged path towards a cure for HIV was one of the themes at the 20th International AIDS Conference (AIDS 2014), taking place this week in Melbourne.

Published
22 July 2014
By
Liz Highleyman
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