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HIV rapidly develops resistance to gene-editing cure technology

In a setback for a novel approach to curing HIV, researchers involved in a technique that uses enzymes to remove viral genes from the DNA of infected

Published
17 May 2016
By
Gus Cairns
HIV took just 2 weeks to overcome our best attempt to edit it out of our cells

We all got really excited a few weeks ago when researchers announced they'd removed HIV from human immune cells using new gene-editing technology called CRISPR/Cas-9, or 'CRISPR' for short, which works like a pair of molecular scissors to cut and paste DNA. As far as we know, that specific result is holding up just fine, but a separate study has now revealed that, worryingly, HIV can evolve to survive CRISPR attacks in just two weeks. Even worse, the attack itself could actually be introducing mutations that make the virus stronger.

Published
11 April 2016
From
ScienceAlert
VRC01 antibody delays but does not prevent HIV rebound after antiretroviral treatment interruption

VRC01, a broadly neutralising antibody targeting HIV's CD4 binding site, was able to modestly delay the return of viral replication following interruption of antiretroviral therapy (ART), according to

Published
08 April 2016
By
Liz Highleyman
Media Outlets Falsely Claim That a Cure for HIV May Be Only Three Years Away

A series of media outlets have erroneously reported that scientists may be just three years away from developing a cure for HIV. This false claim traces to an article published in the United Kingdom’s The Telegraph concerning researchers who recently succeeded in editing HIV’s genetic code out of immune cells in a laboratory setting.

Published
06 April 2016
From
Poz
Gene therapy snips HIV out of infected cells and makes uninfected cells resistant

For the first time, researchers have used a gene-editing technique already used to produce cells resistant to HIV infection to target HIV-infected cells. They have managed

Published
30 March 2016
By
Gus Cairns
Scientists Eliminate HIV from Genome of Human T-Cells

A specialised gene editing system designed by scientists at the Lewis Katz School of Medicine at Temple University is paving the way to an eventual cure for patients infected with HIV. In a study published online this month in the Nature journal, Scientific Reports, the researchers show that they can both effectively and safely eliminate the virus from the DNA of human cells grown in culture.

Published
23 March 2016
From
Temple University
Experimental TLR7 agonist suppresses HIV-like virus in monkeys after ART interruption

GS-9620, an investigational toll-like receptor or TLR7 agonist, led to immune activation in a study of macaque monkeys infected with an HIV-like virus, and two of the animals

Published
29 February 2016
By
Liz Highleyman
Immunotherapy agent can disrupt viral reservoir in SIV-infected monkeys

An immune-enhancing treatment can push SIV (simian immunodeficiency virus) out of its hideouts in infected monkeys that have the virus controlled with drugs, scientists at Yerkes National Primate Research Center, Emory University report.

Published
26 February 2016
From
Emory Health Sciences
Sangamo BioSciences Presents Phase 2 Immunological Data from SB-728-T ZFP Therapeutic® HIV Program at CROI 2016

Subjects from SB-728-1101 cohort 3* remain off antiretroviral therapy for over a year Immunologic and reservoir analyses suggest mechanism for viral load control.

Published
26 February 2016
From
Sangamo Biosciences press release
New molecular scissors cut out lingering HIV—maybe once and for all

With a custom enzyme made through coerced evolution, researchers selectively and reliably sliced HIV sequences from a number of cell types: bacteria, human cell lines used in research, in cells collected from patients with HIV infections, and in “humanized” mice with HIV. Though the strategy is early in development—far from clinical use—the data so far points to an effective and safe way to help drug treatments completely finish off HIV infections.

Published
24 February 2016
From
Ars Technica
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