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Immune-Enhancing Treatment May Destabilize HIV Reservoirs

Findings presented at the 21st International AIDS Conference (AIDS 2016) in Durban, South Africa, suggest that combining ART with an immune-enhancing treatment may destabilize viral reservoirs in macaques infected with simian immunodeficiency virus (SIV), the monkey equivalent of HIV.

Published
21 July 2016
From
NIAID
HIV will only be cured with combinations too, conference delegates hear

Curing people of HIV infection will have to involve combinations of drugs and approaches, just as HIV treatment does, delegates heard at the Towards a Cure workshop

Published
20 July 2016
By
Gus Cairns
Young women treated in very early HIV infection stay HIV negative and preserve immune function

A group of young South African women who were diagnosed in very early infection and immediately given antiretroviral therapy (ART) preserved their CD4 counts and the function

Published
18 July 2016
By
Gus Cairns
NIH Scientists Discover that Defective HIV DNA Can Encode HIV-Related Proteins

Investigators from the National Institutes of Health have discovered that cells from HIV-infected people whose virus is suppressed with treatment harbor defective HIV DNA that can nevertheless be transcribed into a template for producing HIV-related proteins. This finding may affect scientists’ understanding of the long-term effects of HIV infection and what a cure would require.

Published
18 July 2016
From
NIAID
'Classic' HIV Cure Remains a Challenge, NIH Expert Says

History suggests that finding a "classic" cure for HIV -- clearing the virus from the body -- is going to be a tough chore, a top U.S. official said here. On the other hand, a less aspirational goal -- that of achieving sustained remissions from the virus -- looks closer to hand in the current state of medical science, according to Anthony Fauci, MD, director of the NIH's National Institute of Allergy and Infectious Diseases.

Published
17 July 2016
From
MedPage Today
Prospects for developing a cure or sustained remission for HIV take centre stage at AIDS 2016

“HIV cure research became a scientific reality with the launch of the first IAS Global Scientific Strategy: Towards an HIV Cure at AIDS 2012,” noted IAS President Chris Beyrer. “Today, HIV cure research has come into its own as a top HIV research priority, marked by significant advances in our understanding of the scientific challenges and opportunities, more cure-focused research collaborations, and a new optimism that a cure or sustainable remission for HIV is feasible.”

Published
16 July 2016
From
AIDS 2016
Treatment targets HIV's last hiding place

UK scientists may have found a way to destroy HIV's last refuge. A study by Oxford University has confirmed that a treatment developed by a British company can remove the virus in its chosen hiding place, in laboratory conditions, offering hope of a viable treatment.

Published
14 July 2016
From
Eurekalert
NIH expands investment in HIV cure research

The National Institutes of Health has awarded approximately $30 million in annual funding over the next five years to six research collaborations working to advance basic medical science toward an HIV cure.

Published
14 July 2016
From
National Institutes of Health
HIV rapidly develops resistance to gene-editing cure technology

In a setback for a novel approach to curing HIV, researchers involved in a technique that uses enzymes to remove viral genes from the DNA of infected

Published
17 May 2016
By
Gus Cairns
HIV took just 2 weeks to overcome our best attempt to edit it out of our cells

We all got really excited a few weeks ago when researchers announced they'd removed HIV from human immune cells using new gene-editing technology called CRISPR/Cas-9, or 'CRISPR' for short, which works like a pair of molecular scissors to cut and paste DNA. As far as we know, that specific result is holding up just fine, but a separate study has now revealed that, worryingly, HIV can evolve to survive CRISPR attacks in just two weeks. Even worse, the attack itself could actually be introducing mutations that make the virus stronger.

Published
11 April 2016
From
ScienceAlert
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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