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Six questions about HIV/AIDS that deserve more attention

As HIV investigators work to control and eradicate the virus worldwide, certain myths or misconceptions about the disease have been embraced, whereas other concepts with merit have been left relatively unexplored, argues American HIV/AIDS researcher Jay Levy, M.D., in a Trends in Molecular Medicine commentary. He calls on fellow researchers to continue questioning and not to lose sight of alternative strategies that could ultimately lead to a sustainable, long-term solution to HIV infection.

Published
15 April 2015
From
Eurekalert Inf Dis
Human immune system can control re-awakened HIV, suggesting ‘kick and kill’ cure is possible

The human immune system can handle large bursts of HIV activity and so it should be possible to cure HIV with a ‘kick and kill’ strategy, finds new research led by UCL, the University of Oxford and the University of North Carolina at Chapel Hill.

Published
14 April 2015
From
University College London press release
Editing HIV out of our genome with CRISPR

In an attempt to render latent HIV completely harmless, UMass Medical School researchers are using CRISPR/Cas9, a powerful gene editing tool, to develop a novel technology that can potentially cut the DNA of the latent virus out of an infected cell.

Published
13 April 2015
From
University of Massacusetts Medical Schoool press release
An HIV Cure and a Vaccine within the Next 15 Years?

Earlier this year, Bill Gates caused a ripple in the media by expressing optimism that a vaccine and a cure for HIV will become a reality within the next 15 years. From TAG’s perspective, Gates’s buoyancy does have some scientific basis—there have been encouraging signs of progress on both the vaccine and cure fronts in recent years—but the challenges that lie ahead must not be underestimated.

Published
13 April 2015
From
Treatment Action Group
CUREiculum

The CUREiculum is a suite of tools that provides simple, accessible information on HIV cure research, organizing into a systematic format for ongoing or issue-specific learning. The CUREiculum was developed in a multi-collaboratory process by leading scientists, community educators and various advocacy organizations who recognized the need for increasing literacy in this exciting arena. The tools are designed for community educators, funders, media and other stakeholders. Fifteen key areas of HIV cure research have been developed into free standing modules.

Published
08 April 2015
From
AVAC
Experimental agents reverse HIV latency and help immune system fight HIV-infected cells

Researchers at the recent Conference on Retroviruses and Opportunistic Infections (CROI 2015) in Seattle, USA, presented data on several experimental agents that may play a role in achieving

Published
24 March 2015
By
Liz Highleyman
Early antiretroviral treatment reduces, but does not eliminate HIV reservoir

Starting antiretroviral therapy (ART) very soon after infection may limit the size of the HIV 'reservoir' and delay viral rebound after treatment interruption, according to several presentations at

Published
24 March 2015
By
Liz Highleyman
Protection from HIV Without a Vaccine

Last month, a team of scientists announced what could prove to be an enormous step forward in the fight against H.I.V. Scientists at Scripps Research Institute said they had developed an artificial antibody that, once in the blood, grabbed hold of the virus and inactivated it. The molecule can eliminate H.I.V. from infected monkeys and protect them from future infections.

Published
11 March 2015
From
New York Times
Beware Of Sangamo: 20-Year History Of Failures, Misadventures In HIV, And Flawed Approach In B-Thalassemia

Sangamo's purportedly ground-breaking results in HIV with SB-728 do not stand up under close examination. SB-728 has not shown any indication that it can provide a "functional cure" for HIV, does not compare well to today's standard of care, and cannot find a partner. Sangamo refuses to conduct studies that rigorously assess whether their drugs work. This includes the inclusion of a control arm so assiduously avoided by Sangamo's management.

Published
10 March 2015
From
Seeking Alpha
We may need to combine many approaches to achieve a cure, delegates hear

It is unlikely that one single approach will achieve a cure for HIV infection, delegates at a community cure workshop held the day before the Conference on

Published
09 March 2015
By
Gus Cairns
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