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START Study Could Change How We Look at HIV Treatment, and HIV Itself

Have you heard of the START (Strategic Timing of Antiretroviral Treatment) study? In my opinion, it is probably the most important study currently running. It generates strong views, both for and against initiating antiretroviral therapy early, but the results are likely to be surprising.

Published
9 hours ago
From
The Body
NNRTI + 3 NRTIs may be strong first regimen in UKIreland children

Children starting antiretroviral therapy (ART) with a nonnucleoside (NNRTI) plus 3 nucleosides (NRTIs) had the lowest 2-year virologic failure rate in a study of 997 children in the United Kingdom and Ireland. Five-year toxicity rates were similar with the NNRTI and protease inhibitor (PI) regimens studied.

Published
24 November 2014
From
International AIDS Society
Restoring and maintaining a high CD4 count possible for vast majority of people living with HIV in France

A large French study has shown that the vast majority of people living with HIV who started treatment since 2000 in a national cohort achieved a CD4

Published
12 November 2014
By
Alain Volny-Anne
What are the barriers that could stop HIV treatment becoming HIV prevention?

One of the key strategies involved in trying to bring an end to the HIV epidemic is to increase the proportion of HIV-positive people on antiretroviral therapy

Published
12 November 2014
By
Gus Cairns
Once-daily dolutegravir superior to darunavir/ritonavir in 96-week follow-up

Treatment with a triple antiretroviral combination containing once-daily integrase inhibitor dolutegravir (Tivicay) is superior to the ritonavir-boosted protease inhibitor darunavir (Prezista) over 96 weeks of follow-up, Jean-Michel Molina

Published
10 November 2014
By
Alain Volny-Anne
Doravirine works as well as efavirenz with fewer CNS side-effects

Once-daily doravirine (MK-1439), an experimental NNRTI, demonstrated viral suppression similar to that of efavirenz at 48 weeks, and the dose selected for further development was associated with fewer

Published
10 November 2014
By
Liz Highleyman
Early Initiation of Combo Antiretrovirals Gaining Support

Evidence continues to support the initiation of combined antiretroviral therapy soon after HIV infection, researchers report. In fact, the likelihood of the CD4/CD8 ratio normalizing was almost three times greater if antiretroviral therapy was initiated within 6 months of HIV infection than if it was delayed for more than 6 months, according to John Thornhill, MD, from Imperial College London in the United Kingdom, and his team.

Published
07 November 2014
From
Medscape (requires registration)
Do emtricitabine and lamivudine have similar virological efficacy when used in first-line HIV therapy?

First-line antiretroviral regimens containing emtricitabine have superior virological efficacy to combinations containing lamivudine when combined with tenofovir and either nevirapine or efavirenz, Dutch investigators report in the online

Published
03 November 2014
By
Michael Carter
NNRTIs and protease inhibitors both good for first ART, channelling affects choices

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) and boosted protease inhibitors work equally well for people starting HIV treatment for the first time, with similar viral suppression, CD4 cell gains, and disease progression, according to

Published
22 October 2014
By
Liz Highleyman
Effective treatments available for HIV patients not eligible for efavirenz regimens

HIV drug regimens that do not include efavirenz are effective as first-line antiretroviral therapy, a new American clinical trial found. The finding is important for patients who are not eligible for treatment with efavirenz, including women considering becoming pregnant and patients with a history of severe psychiatric disorders.

Published
07 October 2014
From
Science Daily
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