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Guidelines Advise Against Tenofovir for HIV Patients With Kidney Disease

HIV-positive patients who have reduced kidney function should take antiretroviral therapy, but should avoid regimens that contain tenofovir (Viread), according to updated treatment guidelines from the HIV Medicine Association (HIVMA).

Published
22 September 2014
From
The Body Pro
Switch From Efavirenz to Rilpivirine Quells CNS Toxicity, Improves Sleep

Switching from Atripla (efavirenz plus tenofovir/emtricitabine [TDF/FTC]) to Complera (Eviplera, rilpivirine plus TDF/FTC) significantly relieved central nervous system (CNS) toxicity and improved sleep in people with those problems while taking Atripla [1]. All but 1 of 40 study participants who switched in this London/Brighton study maintained virologic control through 24 weeks.

Published
16 September 2014
From
NATAP
New Tenofovir Alafenamide Combo Pill Has Less Effect on Kidneys and Bones

An experimental single-tablet regimen containing a new version of tenofovir (tenofovir alafenamide or TAF) and the HIV protease inhibitor darunavir (Prezista) worked as well as a similar regimen containing the older tenofovir disoproxil fumarate (TDF) formulation,but it had less detrimental effects on kidney function and bone density, as study presented at the recent ICAAC conference heard.

Published
09 September 2014
From
HIVandhepatitis.com
Maraviroc fails to match tenofovir/emtricitabine for first-line HIV treatment

An NRTI-sparing dual antiretroviral regimen containing maraviroc (Celsentri) plus ritonavir-boosted darunavir (Prezista) was found to be less effective than a standard combination with tenofovir/emtricitabine (the drugs in Truvada), according

Published
23 July 2014
By
Liz Highleyman
Drug that reduces abdominal fat in HIV patients also may reduce fat in liver

The only drug to receive Food and Drug Administration approval for reduction of the abdominal fat deposits that develop in some patients receiving antiviral therapy for HIV infection may also reduce the incidence of fatty liver disease in such patients. Massachusetts General Hospital investigators report that six months of daily injections of tesamorelin significantly reduced fat in the liver without affecting glucose metabolism.

Published
19 July 2014
From
Eurekalert Medicine & Health
Common HIV Drug May Boost Suicide Risk

A medication commonly used to treat HIV appears to double the risk that patients will develop suicidal thoughts or take their lives, new research contends. The finding concerns the anti-HIV drug efavirenz, which is marketed as Sustiva.

Published
02 July 2014
From
Web MD
Protease inhibitor therapy increases underlying genetic risk of diabetes for women with HIV

Treatment with an antiretroviral regimen based on a protease inhibitor magnifies any underlying genetic susceptibility to diabetes for women living with HIV, investigators report in the online edition

Published
01 July 2014
By
Michael Carter
Lowering toxicity of new HIV drugs predicted to improve life expectancy

While bringing new drugs to market is important for increasing life expectancy in younger people with HIV, lowering the toxicity of those drugs may have an even greater health impact on all HIV patients, a University of Pittsburgh Graduate School of Public Health analysis reveals.

Published
26 June 2014
From
EurekAlert
In HIV/TB coinfection, raltegravir may be an alternative to efavirenz

Patients coinfected with HIV and tuberculosis (TB) may benefit from raltegravir as an alternative to efavirenz, new research suggests.

Published
02 June 2014
From
Medscape
Risk score can help predict which people living with HIV have highest risk of kidney disease during tenofovir treatment

Investigators in the United States have developed a risk score to predict which people living with HIV have the highest risk of developing chronic kidney disease.

Published
31 March 2014
By
Michael Carter
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