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Antiretroviral Neurotoxicity May Cause Cognitive Problems

As many as 50% of those on combination antiretroviral therapy (cART) suffer from mild to moderate cognitive dysfunction. Antiretroviral medications themselves may be partly to blame for such neurocognitive problems, suggests a recent review of previous studies. But the authors of this review do not recommend that antiretroviral treatment be stopped.

Published
28 January 2015
From
The Body Pro
HIV—Pregnancy-related issues

Themed issue of CATIE's magazine Treatment Update, with several articles on the safety of antiretrovirals during pregnancy.

Published
20 January 2015
From
CATIE
Zimbabwe finally switches away from stavudine

The Zimbabwean government has finally dropped stavudine, lamivudine and nevirapine as its first-line HIV therapy in favour of a single dose treatment which has a combination of three drugs, namely tenofovir/lamivudine/efavirenz (TLN).The Government dropped the first line HIV treatment after realizing that it was causing severe side effects on patients. Stanley Takaona of the Zimbabwe HIV and AIDS Activist Union Community Trust said the introduction of the new HIV drug was going to save more lives.

Published
19 January 2015
From
AllAfrica
Dramatic decline in risk for heart attacks among HIV-positive Kaiser Permanente members

Previously reported increased risk of heart attacks among HIV-positive individuals has been largely reversed in recent years for Kaiser Permanente's California patients, according to a study published in the current online issue of Clinical Infectious Diseases. The adjusted risk ratio for heart attacks among HIV-positive study participants went from an 80 percent increased risk in 1996 to no increased risk in 2010-2011. Reported first on Aidsmap at http://www.aidsmap.com/Heart-attack-risk-in-people-with-HIV-may-be-falling-but-not-in-women/page/2834402/ .

Published
19 January 2015
From
Eurekalert
Viral Load Reductions Persist With Less Efavirenz for HIV

The virologic responses with reduced-dose efavirenz at 48 weeks have proven durable out to 96 weeks, ENCORE1 study results show.

Published
07 November 2014
From
Medscape (requires free registration)
Inflammatory markers associated with development of diabetes in people taking HIV therapy

Low-level elevations in important markers of systemic inflammation are associated with the development of type-2 diabetes in people taking antiretroviral therapy (ART), investigators report in the online edition

Published
20 October 2014
By
Michael Carter
IDWeek 2014: AbbVie 3D HCV Regimen Well-tolerated in PEARL Trials

AbbVie's 3D hepatitis C regimen containing paritaprevir (ABT-450), ombitasvir, and dasabuvir was generally well-tolerated in the Phase 3 PEARL trials, according to a pooled analysis presented at IDWeek 2014 last week in Philadelphia. Serious side effects were uncommon and few people discontinued treatment for this reason.

Published
16 October 2014
From
HIVandHepatitis.com
IDWeek 2014: Efavirenz Not Linked to Suicide in Analysis of Insurance Records

The non-nucleoside reverse transcriptase inhibitor efavirenz (Sustiva, also in the Atripla single-tablet regimen) was not associated with a higher rate of suicidal thoughts or attempts in an analysis conducted by manufacturer Bristol-Myers Squibb (BMS), researchers reported at the 2014 IDWeek meeting last week in Philadelphia.

Published
16 October 2014
From
HIVandHepatitis.com
Effective treatments available for HIV patients not eligible for efavirenz regimens

HIV drug regimens that do not include efavirenz are effective as first-line antiretroviral therapy, a new American clinical trial found. The finding is important for patients who are not eligible for treatment with efavirenz, including women considering becoming pregnant and patients with a history of severe psychiatric disorders.

Published
07 October 2014
From
Science Daily
Why I Refused, Then Later Embraced, HIV Treatment

"On good days, adhering to my pill is a positive affirmation of my life, an exercise in self-love. On bad days, it's just a pill I need to swallow, not terribly bitter but as mildly annoying as having to shave or tie my shoelaces every day. It's yet another thing to add to my list of things, but I do it anyway." Josh Kruger on his ambiguous relationship to HIV treatment.

Published
01 October 2014
From
TheBody.com
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