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Semi-soft vaginal drug-delivery suppository could limit spread of HIV, AIDS

A unique method for delivering compounds that could positively impact the global battle against HIV and AIDS may be possible, thanks to researchers in Penn State's College of Agricultural Sciences. A semi-soft vaginal suppository made from the seaweed-derived food ingredient carrageenan and loaded with the antiviral drug Tenofovir provides a woman-initiated, drug-delivery vehicle that can protect against the spread of sexually transmitted infections during unprotected heterosexual intercourse, the researchers said.

Published
02 September 2014
From
Medical News Today
Weaving HIV protection: UW researchers use fabric to protect women against infection

Scientists use a method of weaving the drug into silk-like fibers that dissolve quickly when inserted into the vagina before sex, delivering a higher dose than is possible with other topical methods currently being tested.

Published
05 August 2014
From
Business Journal
ASPIRE Phase III trial of a vaginal ring for HIV prevention completes enrollment of 2,629 women

MTN’s trial testing dapivirine ring on track to finish next year; IPM’s sister Phase III trial ongoing.

Published
30 June 2014
From
Microbicide Trials Network
Rectal tenofovir gel yields much higher rectal and vaginal levels than oral tenofovir

Tenofovir 1% gel applied rectally yielded rectal tissue concentrations orders of magnitude greater than those achieved with oral tenofovir, according to results of an 18-person study by US researchers. Systemic tenofovir exposure was lower with 1% gel than with oral tenofovir, but vaginal exposure was greater with the rectal gel.

Published
02 June 2014
From
NATAP
IPM Receives Worldwide Rights to HIV Prevention Medicines

The International Partnership for Microbicides (IPM) announced today that it has received exclusive worldwide rights to a promising HIV prevention medicine called dapivirine from Janssen R&D Ireland, one of the Janssen Pharmaceutical Companies of Johnson & Johnson.

Published
09 May 2014
From
International Partnership for Microbicides
Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum

Population Council scientists and their partners have found that their proprietary microbicide gel is safe, stable, and can prevent the transmission of multiple sexually transmitted infections in both the vagina and rectum in animals: HIV, herpes simplex virus 2, and human papillomavirus.

Published
22 April 2014
From
Eurekalert Medicine & Health
HIV incidence is high among pregnant and postpartum women and increases the risk of mother-to-child transmission

HIV incidence is high among pregnant and postpartum women and is associated with an increased risk of mother-to-child transmission (MTCT) of HIV, results of a systematic review and

Published
25 March 2014
By
Michael Carter
Dapivirine vaginal ring safe and effective in tissue study, but maraviroc component doesn't work

Vaginal rings containing the experimental NNRTI dapivirine were well tolerated and blocked HIV infection of cervical tissue samples, but rings containing maraviroc did not produce adequate drug concentrations,

Published
20 March 2014
By
Liz Highleyman
Study: In two-drug, HIV-preventing vaginal ring, only one drug does the job

The National Institutes of Health has shown that a study of its vaginal ring for the prevention of HIV came back with mixed results. The ring, which delivers two drugs, was safe for 28 days, but only one of the antiretroviral drugs was effective in protecting against the virus.

Published
10 March 2014
From
Fierce Drug Delivery
New Rings, Gels, and Films Show Promise in Microbicide Trials

Experimental vaginal microbicides—products such as gels, films, or flexible rings worn inside the vagina—were the focus of two studies reported Tuesday at the 21st Conference on Retroviruses and Opportunistic Infections.

Published
05 March 2014
From
BETA blog
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