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HIV has become more virulent over time, not less, European study finds

The largest cohort study ever to look at CD4 count and viral loads in HIV-positive people around the time of diagnosis has found evidence that HIV, at

Published
10 December 2014
By
Gus Cairns
Is HIV Weakening Over Time?

There has been an explosion of media stories positing that the virulence of HIV is decreasing and that the virus is evolving into a “milder form." But the study prompting the coverage relies primarily on laboratory measurements of HIV replication capacity, despite the fact that a prior publication—by several of the same authors—reports that results from this test do not predict the rate of CD4 T cell decline over time.

Published
03 December 2014
From
TAG
Starting HIV Meds Within a Year of Infection Helps Restore CD4s

Beginning treatment for HIV within a year of infection improves the likelihood of returning an individual’s CD4 count to a normal level.

Published
03 December 2014
From
AIDSMeds
HIV virulence depends on where virus inserts itself in host DNA

The human immunodeficiency virus (HIV) can insert itself at different locations in the DNA of its human host -- and this specific integration site determines how quickly the disease progresses, report researchers at KU Leuven's Laboratory for Molecular Virology and Gene Therapy. The study was published online today in the journal Cell Host & Microbe.

Published
13 November 2014
From
Leuven University, via Eurekalert
The genetics of coping with HIV

We respond to infections in two fundamental ways. One is 'resistance,' where the body attacks the invading pathogen and reduces its numbers. Another, which is much less well understood, is 'tolerance,' where the body tries to minimize the damage done by the pathogen. A study using data from a large Swiss cohort of HIV-infected individuals gives us a glimpse into why some people cope with HIV better than others.

Published
12 November 2014
From
Science Daily
Researchers pinpoint exactly where each building block sits in HIV

Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany and collaborators from Heidelberg University, in the joint Molecular Medicine Partnership Unit, have obtained the first structure of the immature form of HIV at a high enough resolution to pinpoint exactly where each building block sits in the virus. The study, published online today in Nature, reveals that the building blocks of the immature form of HIV are arranged in a surprising way.

Published
04 November 2014
From
Medical Xpress
Immune cells proposed as HIV hideout don't last in primate model

The type of immune cell called macrophages, which have been proposed as a 'sanctuary site' of HIV in the brain and other organs, and as a possible cause of HIV-related brain impairment, don't live long enough to serve as reservoirs of HIV, a study in PLoS Pathogens finds.

Published
04 November 2014
From
EATG
HIV RNA lingers in CSF through up to 10 years of suppressive ART

HIV RNA remained detectable at low levels in cerebrospinal fluid (CSF) of almost 20% of patients who had HIV RNA levels below 40 copies/mL for up to 10 years of antiretroviral therapy (ART). The investigators believe their finding indicates that the central nervous system (CNS) can be an HIV reservoir during suppressive ART.

Published
28 October 2014
From
International AIDS Society
HIV's infection tactics could guide AIDS vaccine, study finds

New research that sheds light on the methods and machinery used by HIV to infect cells provides insight into the tricky virus that potentially could guide the development of a vaccine against the virus that causes AIDS, according to U.S. government and other scientists.

Published
09 October 2014
From
Reuters
Dynamic motion of HIV as it readies an attack: Seen in real time, for the first time

Technologies that allow investigators, for the first time, to watch what they call the 'dance' of HIV proteins on the virus' surface, which may contribute to how the virus infects human immune cells, have been developed by scientists. The new technology platform opens new possibilities for devising an approach to prevent HIV infection, note researchers

Published
09 October 2014
From
Science Daily
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