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Low CD4 cell count increases the risk of several cancers after starting HIV therapy

A large US study has provided important new insights into the incidence and timing of cancers among people taking antiretroviral therapy. Published in the online edition of

Published
12 June 2013
By
Michael Carter
New Danish results spark interest for future HIV cure research

Danish scientists have been doing some interesting cure research that may have gone underappreciated.

Published
12 June 2013
From
CATIE
New FDA Guidance for Industry: Developing Antiretroviral Drugs for Treatment

Significant changes from the 2002 version include: more details on nonclinical development of antiretroviral drugs; a greater emphasis on recommended trial designs for HIV-1-infected heavily treatment-experienced patients (those with multiple-drug resistant virus and few remaining therapeutic options); use of a primary endpoint evaluating early virologic changes for studies in heavily treatment-experienced patients; and use of the traditional approval pathway for initial approval of new antiretrovirals with primary analysis time points dependent on the indication sought.

Published
11 June 2013
From
US Food and Drug Administration
High rate of spontaneous disease regression in men with high-grade pre-cancerous anal lesions

High-grade pre-cancerous anal lesions are more likely to regress than progress, according to Australian research published in the online edition of AIDS. The study involved 574 men, three-quarters

Published
10 June 2013
By
Michael Carter
Am I mad or is it the meds?

It’s 00:50 and once again I can’t sleep. My insomnia has kept me up for the best part of three days in a row now, my mind is tired, my body is exhausted and yet I still can’t sleep.

Published
07 June 2013
From
UK Positive Lad (blog)
Bone loss and fracture risk are 'modest' among HIV+ people, linked to tenofovir, smoking, and HCV

Continued bone loss among HIV positive men with osteopenia was modest overall, but about 25% of those taking tenofovir (Viread, also in 4 antiretroviral coformulations) experienced significant loss, according to a recent study. A related meta-analysis found that HIV infection is associated with a modest likelihood of new fractures, with smoking and hepatitis C virus (HCV) coinfection further increasing the risk.

Published
07 June 2013
From
HIVandHepatitis.com
NIH scientists discover how HIV kills immune cells

Untreated HIV infection destroys a person's immune system by killing infection-fighting cells, but precisely when and how HIV wreaks this destruction has been a mystery until now. New research by scientists at NIAID reveals how HIV triggers a signal telling an infected immune cell to die. This finding has implications for preserving the immune systems of HIV-infected individuals.

Published
07 June 2013
From
Eurekalert Inf Dis
People doing well on HIV therapy have a mortality risk identical to that of HIV-negative peers

HIV-positive people taking antiretroviral therapy who have an undetectable viral load and a CD4 cell count above 500 cells/mm3 have a mortality risk comparable to that seen

Published
05 June 2013
By
Michael Carter
Liquid Injectable Silicone Effective, Safe for Treating HIV Patients with Facial Lipoatrophy

Research in British Columbia, Canada, indicates that liquid injectable silicone administered properly has potential as a safe, effective, natural feeling treatment for patients with HIV-associated facial lipoatrophy (FLA). The researchers tested liquid injectable silicone because temporary filler treatments were not permanent and could result in high costs.

Published
04 June 2013
From
Healio
Is Long-Term Treatment Better with Raltegravir Than with Efavirenz?

Five-year follow-up of a blinded, prospective clinical trial demonstrated that raltegravir has a better side-effect profile, which ultimately leads to better outcomes.

Published
04 June 2013
From
Journal Watch

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