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Drug interactions and pharmacokinetics news

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TB treatment
Dosing of key TB drug rifampicin could go higher

Rifampicin, a key drug in tuberculosis (TB) treatment, can be tolerated at much higher doses than used in current clinical practice – suggesting that much higher drug

Published
07 March 2013
By
Keith Alcorn
Drug interactions and pharmacokinetics
Prezista (darunavir) label change - drug interaction information

The FDA recently approved changes to the Prezista (darunavir) label to reflect drug interaction information with artemether/lumefantrine. The specific changes are outlined below.

Published
02 March 2013
From
US Food and Drug Administration
Treatment guidelines
Updated HIV Treatment Guidelines Include Stronger Recommendation for Acute Infection

Among the key changes are additional information about the most recently approved antiretroviral agents and a recommendation that newly infected people with HIV should be offered combination ART. The guidelines continue to recommend treatment for all people with HIV, both to reduce the risk of disease progressionand for the prevention of HIV transmission.

Published
15 February 2013
From
HIVandHepatitis.com
Hepatitis C treatment side-effects
Drug interaction warning for hepatitis C: serious side effects when using telaprevir and bosentan

A medical team in Paris, France, has reported an unexpected and disturbing drug interaction between a drug used to treat pulmonary arterial hypertension—bosentan (Tracleer)—and the HCV drug telaprevir. The interaction led to serious side effects.

Published
15 February 2013
From
CATIE
Treatment guidelines
Updated U.S. DHHS guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents

New recommendations on drug-resistance testing, genotypic tropism assays, starting treatment, acute infection, pregnancy and interactions.

Published
15 February 2013
From
AIDSinfo
Drug interactions and pharmacokinetics
Certain Meds Mixed With Grapefruit Juice Can Be a Fatal Cocktail

The scientist who discovered that grapefruit can alter  drug levels in the body has released an updated list of 85 medications that may cause such reactions, in order to reflect releases of new medications over the past four years.

Published
21 December 2012
From
AIDSMeds
Contraception
Combined oral contraception has less effect on nevirapine than efavirenz levels

HIV therapy based on efavirenz may less suitable for women taking combined oral contraception due to greater reductions in efavirenz levels and a higher frequency

Published
21 December 2012
By
Michael Carter
Drug interactions and pharmacokinetics
Mistakes are still commonly made in prescriptions of antiretroviral medications

Research presented at IDWeek 2012- concludes that despite advances in electronic medical records, mistakes are still commonly made in the prescription of antiretroviral medications for hospitalized HIV-positive patients. At the same time, a trio of studies suggests however, that electronic records in combination with increased clinical education can help to greatly decrease medical errors.

Published
22 October 2012
From
News Medical
Side-effects
CNS symptoms common in people taking raltegravir

Approximately 10% of patients taking the antiretroviral drug raltegravir (Isentress) develop central nervous system (CNS) side-effects, research published in the online edition of AIDS shows. The development of CNS

Published
10 October 2012
By
Michael Carter
TB treatment
Raltegravir 800mg twice daily appears a good alternative to efavirenz for HIV-TB treatment

Raltegravir seems to be a suitable alternative to efavirenz for HIV-TB co-infected patients while receiving TB treatment, according to 24-week results of the ANRS 12 180 REFLATE

Published
31 July 2012
By
Lesley Odendal
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