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Drug interactions and pharmacokinetics news

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Intermittent PrEP may be a robust strategy for anal sex – vaginal much less certain

The pharmacodynamics (drug absorption and elimination rates) of the two drugs that comprise Truvada may favour the efficacy of intermittent pre-exposure prophylaxis (PrEP) more than previously thought, at

Published
22 July 2015
By
Gus Cairns
Geriatric HIV: living with multiple medical conditions will become the norm as population ages

In fifteen years' time, the clinical needs of Dutch people living with HIV will have changed substantially due to three quarters of them being over the

Published
16 June 2015
By
Roger Pebody
'Lab on a card' can spot poor quality drugs

The tool is known as a PAD (Paper Analytical Device) and is essentially a mini lab on a piece of card, Mercy explains. "It's simple, you apply the tablet on a specific area on the device, dip the card in water and wait for a colour reaction, then compare the results to a standard to interpret the results." Each of the cards contains 12 separate strips which react with a drug to create a "coloured bar code" that gives information about its chemical content.

Published
08 June 2015
From
BBC Health
Almost Three Quarters of HIV/HCV Group May Have DDA-ARV Interactions

Among 125 HIV/HCV-coinfected people taking antiretrovirals in a Denver group, 70% could have moderate or severe interactions with one of four common direct-acting antiviral (DAA) regimens for HCV.

Published
02 June 2015
From
NATAP
Lower daily tenofovir dose of 150mg safe and effective in people with moderate renal impairment

A reduced tenofovir (Viread) dose of 150mg daily appears to be a safe and effective treatment for people with HIV who have moderate renal impairment, investigators from

Published
22 May 2015
By
Michael Carter
Sofosbuvir/ledipasvir raises some antiretroviral levels in HIV/HCV coinfected people

People with HIV and hepatitis C virus (HCV) co-infection who take sofosbuvir/ledipasvir (Harvoni) to treat hepatitis C along with boosted protease inhibitor antiretroviral regimens may experience changes

Published
10 March 2015
By
Liz Highleyman
Isentress (raltegravir) label update

On February 18, 2015, FDA approved changes to the Isentress (raltegravir) label to include updated information regarding the coadministration of raltegravir and aluminum and/or magnesium containing antacid.

Published
19 February 2015
From
FDA
Viral Load Reductions Persist With Less Efavirenz for HIV

The virologic responses with reduced-dose efavirenz at 48 weeks have proven durable out to 96 weeks, ENCORE1 study results show.

Published
07 November 2014
From
Medscape (requires free registration)
Efavirenz compromises hormonal contraceptive implant

The widely prescribed non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz substantially reduces levels of the hormonal contraceptive levonorgestrel, a component of a progesterone contraceptive implant widely used in

Published
03 November 2014
By
Keith Alcorn
Change to recommended regimen for post-exposure prophylaxis (PEP)

The Expert Advisory Group on AIDS (EAGA) has recommended a change in the recommended regimen for post-exposure prophylaxis from tenofovir/emtricitabine with Kaletra to tenofovir/emtricitabine with raltegravir.

Published
11 September 2014
From
Expert Advisory Group on AIDS (EAGA)
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