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It depends on your reason for changing treatment. If you are switching because you have drug resistance or your treatment has not been keeping your viral load to an undetectable level, then you definitely need a new treatment. It would not be a good idea to return to your original drugs. But your doctor may be able to suggest an alternative combination to take.

However, if you are switching because of side effects, you will have more options. Sometimes people are nervous about changing treatment, worrying that their new treatment will also have side effects and that these could be more difficult to live with. This is unlikely, but if it does happen, you’ll probably be able to go back to the anti-HIV drugs you were on before.

Roger Pebody

Roger Pebody

Commissioning Editor

Roger joined aidsmap in 2008 and was Managing Editor from 2018 to 2024. As a freelancer, he now edits aidsmap’s news and conference coverage, as well as working on updates to About HIV pages. He is also a contributing science editor for TheBodyPro, a freelance journalist for The Lancet HIV, and a medical writer helping researchers prepare articles for peer-reviewed journals. He began working on HIV at Gay Men Fighting AIDS in the mid-1990s.

How treatment works

How treatment works

Taking drugs on time

Taking drugs on time

Drug resistance

Drug resistance

Side effects

Side effects

HIV and the immune system

HIV and the immune system

Myths and facts

Myths and facts

What should I do if I throw up after taking my HIV meds?

How long will it take for HIV to develop resistance to my medications?

My HIV is undetectable, can I stop my medication?

A white pill bottle is tipped over with white pills spilling out.

What is an elite controller?

Starting HIV treatment

Pill in hand

Recommended treatments for HIV

A man in a blue t-shirt gets HIV treatment out of a blister pack.

One-pill-a-day HIV treatments

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Anti-HIV drugs

Anti-HIV drugs booklet

Taking your HIV treatment

Taking your HIV treatment booklet

An introduction to HIV medicines

An introduction to HIV medicines

Why taking your HIV treatment properly is important

Image: Domizia Salusest | www.domiziasalusest.com

Adherence to HIV treatment

Image: Domizia Salusest | www.domiziasalusest.com

Food requirements for anti-HIV medications

People sit outside at a table with a close up of a hand with pills in it.

Resistance to anti-HIV drugs

Image: Domizia Salusest | www.domiziasalusest.com

What happens to HIV drugs in the body, and do missed doses matter?

Mareike Günsche | www.aspect-us.com

Interactions between HIV medication and recreational drugs

Two syringes, powder and spoon on old wooden background.

Changing HIV treatment

A man in a bathroom holding two bottles of medication and reading the label of one of them.

HIV treatment breaks

A white pill bottle is tipped over with white pills spilling out on to a table.

Should HIV controllers take HIV treatment?

A doctor and patient talking in a doctor's office.

HIV lifecycle

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The stages of HIV infection

An illustration of an HIV virus.