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Experimental agents reverse HIV latency and help immune system fight HIV-infected cells

Researchers at the recent Conference on Retroviruses and Opportunistic Infections (CROI 2015) in Seattle, USA, presented data on several experimental agents that may play a role in achieving

Published
24 March 2015
By
Liz Highleyman
Early antiretroviral treatment reduces, but does not eliminate HIV reservoir

Starting antiretroviral therapy (ART) very soon after infection may limit the size of the HIV 'reservoir' and delay viral rebound after treatment interruption, according to several presentations at

Published
24 March 2015
By
Liz Highleyman
Protection from HIV Without a Vaccine

Last month, a team of scientists announced what could prove to be an enormous step forward in the fight against H.I.V. Scientists at Scripps Research Institute said they had developed an artificial antibody that, once in the blood, grabbed hold of the virus and inactivated it. The molecule can eliminate H.I.V. from infected monkeys and protect them from future infections.

Published
11 March 2015
From
New York Times
Beware Of Sangamo: 20-Year History Of Failures, Misadventures In HIV, And Flawed Approach In B-Thalassemia

Sangamo's purportedly ground-breaking results in HIV with SB-728 do not stand up under close examination. SB-728 has not shown any indication that it can provide a "functional cure" for HIV, does not compare well to today's standard of care, and cannot find a partner. Sangamo refuses to conduct studies that rigorously assess whether their drugs work. This includes the inclusion of a control arm so assiduously avoided by Sangamo's management.

Published
10 March 2015
From
Seeking Alpha
We may need to combine many approaches to achieve a cure, delegates hear

It is unlikely that one single approach will achieve a cure for HIV infection, delegates at a community cure workshop held the day before the Conference on

Published
09 March 2015
By
Gus Cairns
Markers of Immune Exhaustion Predict Post-Treatment Control in HIV Patients

Biomarkers of immune exhaustion were associated with how long a patient was able to control HIV after treatment was interrupted, according to a study presented at CROI 2015.

Published
05 March 2015
From
The Body
Study of potential HIV 'cure' wins FDA nod

The trial at the City of Hope medical center will take blood-producing stem cells from patients infected with HIV and use a kind of molecular scissors — enzymes called zinc finger nucleases — to edit a protein that the virus uses to infect cells. The method was developed by Richmond's Sangamo BioSciences Inc.

Published
04 March 2015
From
San Francisco Business Times
Doctor who cured ‘Berlin patient’ of HIV: ‘We knew we were doing something very special’

Dr. Gero Hütter and Timothy Ray Brown speak about the transplant that forever linked them in medical history.

Published
02 March 2015
From
Fred Hutch News
New clues about viral rebound in Mississippi child thought cured of HIV

Clinicians involved in the care of a child many once hoped was cured of HIV have published details about the case in the New England Journal of Medicine. The authors found that the virus that eventually returned after the girl had been off antiretroviral therapy for more than 2 years was identical to her mother's viral strain. The case shows that HIV establishes a viral reservoir very soon after infection. Starting antiretroviral treatment a day after birth was not enough to prevent viral rebound, though it did appear to allow prolonged remission.

Published
23 February 2015
From
HIVandHepatitis.com
Biologist's Work on 'Viral Reservoirs' May Have Impact on AIDS/HIV

A drug used to treat patients with multiple sclerosis and Crohn’s disease has confirmed how “viral reservoirs” form in patients living with HIV and AIDS and also proven effective in animal trials at blocking the pathways to those reservoirs in the brain and gut, according to new research conducted by Professor of Biology Ken Williams and colleagues from other universities.

Published
19 February 2015
From
Boston College Chronicle
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