Eviplera is a single-tablet regimen, combining rilpivirine, emtricitabine and tenofovir disoproxil fumarate in one pill, taken once a day.

Do not take Eviplera with the anticonvulsants carbamazepine, oxcarbazepine, phenobarbital or phenytoin, or St John’s wort. Eviplera should not be taken at the same time as the antibiotics rifampicin and rifabutin (often used to treat TB). Some other antibiotics can increase blood levels of the rilpivirine in Eviplera.

Medicines that affect stomach acidity can block the way Eviplera is absorbed. Don’t take proton pump inhibitors (PPIs), such as omeprazole, lansoprazole with Eviplera.

Indigestion remedies called H2-blockers (such as ranitidine, Zantac) should be taken at least 12 hours before or at least four hours after taking Eviplera. If you are taking other indigestion remedies (such as Rennies or Gaviscon) or calcium supplements, they should be taken at least two hours before or at least four hours after taking Eviplera as they can prevent it being absorbed properly.

Lactic acidosis (too much lactic acid in the blood), kidney failure.

Raised cholesterol and triglyceride levels, loss of appetite, depression, sleep disorders, abnormal dreams, sleepiness, nausea, vomiting, diarrhoea, dizziness, insomnia, headache, weakness, rash, itching, abdominal pain, dry mouth, fatigue, bloating, flatulence, changes in kidney function, raised liver enzyme, amylase and creatine kinase levels, low blood phosphate levels, skin darkening, low white blood cell count.

Always take with food, such as your main meal of the day, otherwise you will not absorb enough rilpivirine and your treatment may fail.

Triple-drug combination in one tablet, taken once a day. Combines 200mg emtricitabine, 245mg tenofovir disoproxil (both NRTIs), and 25mg of rilpivirine (an NNRTI) in a purplish-pink tablet.