Dovato is a single-tablet regimen, combining dolutegravir and lamivudine in one pill, taken once a day.

You should not take Dovato if you are currently taking cladribine (chemotherapy) or medicines containing sorbitol, xylitol, mannol, lactitol, maltitol (may be present as fillers in liquid medicines).

Antacids containing magnesium should be taken at least 6 hours before or 2 hours after Dovato. Calcium supplements, iron supplements or multivitamins should be taken at the same time as Dovato, with a meal.

If Dovato is used with St John’s Wort, the tuberculosis treatment rifampicin or the anticonvulsants carbamazepine, phenobarbital, phenytoin or oxcarbazepine, an additional 50mg tablet of dolutegravir should be taken 12 hours after Dovato.

Allergic (hypersensitivity) reaction, liver inflammation, lactic acidosis, liver damage.

Headache, dizziness, drowsiness, tiredness, depression, anxiety, difficulty in sleeping, abnormal dreams, nausea, diarrhoea, abdominal pain, vomiting, flatulence, increased liver enzymes or creatinine phosphokinase, rash, itching, hair loss, muscle and joint pains.

Dolutegravir: An allergic (hypersensitivity) reaction has been reported in some people taking dolutegravir. This is rare, but you should see a doctor immediately if you think you are experiencing an allergic reaction. The symptoms are skin rash; fever; fatigue; swelling, sometimes of the face or mouth, causing breathing problems; muscle or joint aches.

Take with or without food.

Combination treatment in one tablet, taken once a day. Combines 50mg dolutegravir (an integrase inhibitor) and 300mg lamivudine (an NRTI) in a white tablet.