Rezolsta combines darunavir and cobicistat, which is used to boost the effect of darunavir, in one pill. It is taken in combination with other antiretroviral drugs.

You should not take Rezolsta with any of the following drugs: alfuzosin, amiodarone, astemizole, avanafil, bepridil, carbamazepine, cisapride, colchicine, dronedarone, ergot alkaloids (ergotamine, dihydroergotamine, ergometrine, methylergonovine), lidocaine, lovastatin, midazolam, phenobarbital, phenytoin, pimozide, quetiapine, quinidine, ranolazine, rifampicin, sertindole, sildenafil, simvastatin, St John’s wort, terfenadine, ticagrelor, triazolam.

If you are taking darunavir, it is particularly important to check with your HIV doctor or pharmacist before taking other medicines, as these may interact with darunavir or with the boosting drugs ritonavir or cobicistat.

Some common drugs may be affected, including antibiotics, corticosteroids, hormonal contraceptives, metformin, methadone and statins.

The drug works well in many people with resistance to other protease inhibitors.

Abnormal liver function, changes in heart rhythm.

Diarrhoea, vomiting, nausea, indigestion, rash, itching, abdominal pain, bloating, flatulence, headache, fever, difficulty in sleeping, tiredness, diabetes, raised creatine or amylase or triglyceride or cholesterol or liver enzyme levels.

Always take Rezolsta with food to improve absorption.

Combines 800mg darunavir and 150mg cobicistat (to boost the darunavir) in a pink, oval tablet. The usual adult dose is one tablet taken once a day.