Odefsey is a single-tablet regimen, combining rilpivirine, emtricitabine and tenofovir alafenamide in one pill, taken once a day.

Do not take Odefsey with the anticonvulsants carbamazepine, oxcarbazepine, phenobarbital or phenytoin; dexamethasone (a corticosteroid medicine used to treat inflammation and suppress the immune system); or St John’s wort.

Odefsey should not be taken at the same time as the antibiotics rifampicin and rifabutin (often used to treat TB). Some other antibiotics can increase blood levels of the rilpivirine in Odefsey.

Medicines that affect stomach acidity can block the way Odefsey is absorbed. Don’t take proton pump inhibitors (PPIs), such as omeprazole, lansoprazole or pantoprazole. Indigestion remedies called H2-blockers (such as ranitidine, Zantac) should be taken at least 12 hours before or at least four hours after taking Odefsey. If you are taking other indigestion remedies (such as Rennies or Gaviscon) or calcium supplements, they should be taken at least two hours before or at least four hours after taking Odefsey as they can prevent it being absorbed properly.

Not suitable for use by people with NNRTI resistance.

Severe rash and fever.

Difficulty in sleeping, abnormal dreams, depression, headache, dizziness, loss of appetite, nausea, abdominal pain, vomiting, dry mouth, indigestion, flatulence, diarrhoea, rash, tiredness, low white or red blood cell count, low platelet count, raised lipid or pancreatic enzyme or liver enzyme levels.

Always take with food, such as your main meal of the day, otherwise you will not absorb enough rilpivirine and your treatment may fail.

Triple-drug combination treatment in one tablet, taken once a day. Combines 200mg emtricitabine, 25mg of tenofovir alafenamide (both NRTIs) and 25mg of rilpivirine (an NNRTI) in a grey, capsule-shaped, film-coated tablet.