Juluca is a single-tablet regimen combining dolutegravir and rilpivirine in one pill, taken once a day.

You should not take Juluca if you are currently taking products that contain St John’s wort (a herbal remedy used for depression and anxiety); rifampicin and rifapentine (used to treat some bacterial infections such as TB); carbamazepine, oxcarbazepine, phenobarbital and phenytoin (used to treat epilepsy and prevent seizures); proton pump inhibitors, such as omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole (used to treat acid reflux); systemic dexamethasone (anti-inflammatory steroid, many uses for treatment of serious conditions); dofetilide (treatment for irregular heartbeat).

H2-recepter antagonists such as famotidine, used to reduce the amount of stomach acid, should be taken at least 4 hours after or 12 hours before Juluca.

Antacids containing magnesium should be taken at least 6 hours before or 4 hours after Juluca.

Calcium supplements, iron supplements or multivitamins should be taken at the same time as Juluca, with a meal.

Suicidal thoughts and behaviour.

Difficulty in sleeping, abnormal dreams, depression, depressed mood, anxiety, headache, dizziness, drowsiness, fatigue, nausea, diarrhoea, abdominal pain, vomiting, flatulence, dry mouth, decreased appetite, increased liver enzymes or bilirubin or creatinine phosphokinase or lipase or pancreatic amylase, decreased white blood cell count, haemoglobin or platelet count, increased total or LDL cholesterol, increased triglycerides, rash, itching.

Dolutegravir: An allergic (hypersensitivity) reaction has been reported in some people taking dolutegravir. This is rare, but you should see a doctor immediately if you think you are experiencing an allergic reaction. The symptoms are skin rash; fever; fatigue; swelling, sometimes of the face or mouth, causing breathing problems; muscle or joint aches.

Take with a meal.

Combination treatment in one tablet, taken once a day. Combines 50mg of dolutegravir (an integrase inhibitor) and 25mg of rilpivirine (an NNRTI) in a pink tablet.