Doravirine is marketed under the name Pifeltro. It is taken in combination with other antiretroviral drugs.

You should not take doravirine if you are currently taking the following medicines: carbamazepine, oxcarbazepine, phenobarbital, phenytoin (drugs used to treat epilepsy and seizures); rifampicin, rifapentine (treatment for tuberculosis); St John's wort (Hypericum perforatum) (a herbal remedy used for depression and anxiety); mitotane (a cancer treatment); enzalutamide (a treatment for prostate cancer); lumacaftor (treatment for cystic fibrosis).

Resistance to doravirine is likely to lead to resistance to efavirenz and rilpivirine.

Suicidal thoughts, acute kidney injury.

Abnormal dreams, difficulty in sleeping, nightmare, depression, headache, dizziness, drowsiness, nausea, diarrhoea, abdominal pain, vomiting, rash, tiredness.

Doravirine can be taken with or without food.

The usual adult dose is one 100mg white tablet taken once a day. Doravirine is also available in the combination tablet Delstrigo.