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FDA Advisory Committee Votes Favorably on the Question of the Effectiveness and Safety of Pretomanid in Combination with Bedaquiline and Linezolid for Treatment of Highly Drug-Resistant Forms of Tuberculosis

Investigational drug pretomanid, developed by non-profit TB Alliance, is under regulatory review for treatment of extensively drug-resistant tuberculosis and treatment-intolerant or non-responsive multidrug-resistant tuberculosis as part of a new investigational regimen that includes bedaquiline and linezolid.

Published
07 June 2019
From
TB Alliance
Drug resistant strains could become the dominant form of TB in Europe: it’s time to end TB

If the current situation continues, the majority of tuberculosis (TB) patients in the next generation could be suffering from drug resistant forms of the disease. The latest WHO/European Centre for Disease Prevention and Control (ECDC) report, “Tuberculosis surveillance and monitoring in Europe 2019 (2017 data)”, shows that the European Region is struggling to make sufficient progress to finally end TB. Challenges in timely detection, which result in ongoing transmission, and inadequate treatment are driving resistance. Despite an overall decline in cases, TB remains a major public health issue that is causing patients suffering and perpetuating poverty.

Published
25 March 2019
From
World Health Organization Europe
'Short' drug-resistant TB regimen could cut treatment time by more than half

A new drug cocktail reduces the length of treatment for multidrug-resistant tuberculosis from nearly two years to nine to 11 months with a similar effectiveness, according to a large clinical trial whose results were published in a US journal Wednesday.

Published
14 March 2019
From
FRANCE 24
TB CAB statement on safety of using bedaquiline and delamanid together

he Global TB Community Advisory Board (TB CAB) welcomes the important finding from the AIDS Clinical Trials Group Deliberate Trial that newer drugs bedaquiline and delamanid are safe to use together. These findings should erase any remaining reluctance to use these two important drugs together, as the benefits of these safer drugs outweigh the risks--especially for patients with drug-resistant TB who have few other treatment options.

Published
14 March 2019
From
TB Online
Deadly drug-resistant TB a ‘blinking red’ global threat

“We should all be more worried about multidrug-resistant TB than we are. It gets nothing like the level of attention it should do,” Peter Sands, Global Fund’s head, told AFP during a visit to New Delhi.

Published
07 February 2019
From
South China Morning Post
Vitamin D helps treat lethal drug-resistant TB

Vitamin D has been found to speed up the clearance of tuberculosis (TB) bacteria from the lungs of people with multi-drug resistant TB, according to a study of 1,850 patients receiving antibiotic treatment, led by Queen Mary University of London.

Published
07 February 2019
From
Eurekalert Inf Dis
Glimmers of hope: moving towards better HIV and TB treatment in eastern Europe

Eastern Europe continues to have one of the worst HIV epidemics in the world outside sub-Saharan Africa, with the worst linkage to care of any region in

Published
07 February 2019
By
Gus Cairns
Despite side-effects, docs promote old TB treatment

At a recent international TB conference, some doctors suggested countries with weak health systems should not be allowed to use new TB drugs, although the old ones are ineffectual and cause deafness. Thankfully, South Africa is leading the world in treating drug-resistant TB.

Published
26 November 2018
From
Health-e
49th Union World Conference on Lung Health: 90 percent of participants in short-course XDR-TB regimen cured after six months

New results from the ongoing Nix-TB trial continue to confirm a short-course treatment regimen of bedaquiline – one of the two newest drugs to treat TB in half a century – linezolid and pretomanid offers a significantly improved treatment option for people infected with drug resistant forms of tuberculosis, researchers said here.

Published
05 November 2018
From
Science Speaks
Bedaquiline price protests hit World Lung Conference launch

As the opening ceremony of the 49th Union World Conference on Lung Health kicked off in the Netherlands last night, protesting activists demanded Johnson & Johnson (J&J) slash its price for the blockbuster tuberculosis (TB) drug, bedaquiline.

Published
26 October 2018
From
Health-e
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.