News and information about basic science that may lead researchers to develop a cure for HIV – studies of the latent viral reservoir, shock and kill approaches, gene therapies, immune modulators therapeutic vaccines, broadly neutralizing antibodies and so on.

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  • What’s the fuss about a functional cure?

    A recent study from researchers in Hong Kong has got the world’s media talking about a functional cure for HIV. A quick search for the terms ‘HIV, functional cure, Hong Kong’ yields a long list of articles and videos from around the world. Twitter has also been going crazy. Read on to find out what the researchers did, what they found, and more importantly, what this means for people living with HIV.

    21 hours ago | HIV Cure
  • Strategies for a cure

    Three researchers talk with PA editor Jeff Berry about ongoing HIV cure research within the ACTG, treatment interruptions, and when we might see a cure.

    12 June 2018 | Positively Aware
  • People with Innate Resistance to HIV Could Provide a Functional HIV Cure

    In the process of studying HIV-infected patients who naturally don’t need therapy to control the virus, scientists have found what could become a functional cure for HIV infections.

    11 June 2018 | Labiotech.eu (blog)
  • CRISPR Eradicates Latent HIV-1, Offering Hope of "Functional Cures"

    Scientists in Japan have used CRISPR-Cas9 technology to stop human immunodeficiency virus type 1 (HIV-1) replication in latently infected T cells that can’t be controlled using existing drug treatments. The gene-editing approach effectively disrupts two regulatory HIV-1 genes, tat and rev, which are essential for viral replication.

    22 May 2018 | Genetic Engineering & Biotechnology News
  • Discovery of how HIV hedges its bets opens the door to new therapies

    HIV covers its bases in a volatile environment by generating both active and dormant infections. But if the virus is randomly switching between these two fates, how does it ever commit to remaining in one state? Weinberger's laboratory has now answered this longstanding question. Researchers may now be able to continually force HIV back into latency by exploiting the virus's splicing circuit and achieve the "lock and block" therapy.

    11 May 2018 | Eurekalert Medicine & Health
  • Gene editing holds promise for shrinking HIV ‘reservoir’

    Study mimicking Timothy Ray Brown’s HIV-resistant mutation led to fewer latently infected cells — a key step toward driving the virus into remission without the need for antivirals

    27 April 2018 | Fred Hutch
  • Top HIV cure research team refutes major recent results on how to identify HIV persistence

    An international team focused on HIV cure research spearheaded by The Wistar Institute in collaboration with the University of Pennsylvania and Vall d'Hebron Research Institute (VHIR) in Barcelona, Spain, established that the CD32 molecule is not a preferential biomarker to identify HIV silent reservoirs within the immune system of patients undergoing antiretroviral therapy (ART), as proposed by a recent landmark study.

    19 April 2018 | Medical Xpress
  • Gene Regulation May Overpower Hidden HIV Reserves

    New research published in The Journal of Clinical Investigation suggests that an epigenetic mechanism that controls gene expression may draw HIV out of hiding and make it vulnerable to ART.

    16 March 2018 | Specialty Pharmacy Times
  • Scientists Find No Signs That Well-Treated HIV Replicates in Lymph Nodes

    A research team has found no evidence of ongoing HIV replication in the lymph nodes among individuals receiving fully suppressive antiretroviral (ARV) treatment for the virus. This finding stands in sharp contrast to the conclusions of a 2016 study out of Northwestern University, published in Nature, that indicated that even in the face of ARV treatment, HIV replicates in the lymph nodes, thus helping to replenish the viral reservoir.

    06 March 2018 | Poz
  • Case Western Reserve and Sangamo Therapeutics Announce $11 Million NIH Grant for Study of Gene-Edited T Cells for Viral Eradication of HIV

    The grant will fund a clinical trial to test the hypothesis that treating patients with their own gene-edited T cells may lead to a sustained increase in T cell counts and eradication of latent HIV reservoirs.

    07 February 2018 | Sangamo press release
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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