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  • Dolutegravir preconception signal: time is up for shoddy surveillance

    The news in May 2018 of a potential risk of neural tube defects in infants born to women taking dolutegravir (DTG) at the time of conception sent shockwaves through the HIV community. But, despite massive global investment, aggressive transition plans – as well as calls for years for more systematic recording of outcomes when women receive ART in pregnancy– few prospective birth registrieshave been established in other settings that can refute or confirm this finding. Meanwhile, women of child-bearing age, whether they intend to become pregnant or not, are being told that they must stick with (or go back to) efavirenz (EFV) – a drug that, before this news, was in the process of being replaced with DTG.

    16 July 2018 | HIV i-Base
  • Dolutegravir: need to consider all pros and cons before switching in pregnancy

    A young pregnant woman who switched from dolutegravir (DTG)-based ART, in response to the neural tube defect safety signal, experienced viral rebound on her new regimen. She needed to be switched back to DTG to achieve re-suppression and prevent vertical transmission.

    11 July 2018 | HIV i-Base
  • New contraindication against using darunavir/cobicistat during pregnancy

    On 22 June 2018, Janssen issued a Dear Doctor letter (linked below) against using darunavir/cobicistat during pregnancy. This new contraindication is based on significantly reduced plasma levels of darunavir and cobicistat during the second and third trimesters of pregnancy. Darunavir can still be used during pregnancy, but only when boosted by ritonavir.

    25 June 2018 | HIV i-Base
  • Yes, HIV-Positive Men Can Become Fathers. Here's Two Providers Who Help Them

    In HIV, we pay a lot of attention to parenthood -- but mostly from the perspective of ending mother-to-child transmission. Even then, the public health message is often mostly about the baby, not the health and well-being of the mother. But almost nowhere do we have deep discussions about reproductive options for HIV-positive men, particularly cisgender straight men.

    18 June 2018 | TheBody.com
  • Nigeria has more HIV-infected babies than anywhere in the world. It’s a distinction no country wants

    At a time when rates of mother-to-child transmission of HIV have plummeted, even in far poorer countries, Nigeria accounted for 37,000 of the world’s 160,000 new cases of babies born with HIV in 2016.

    13 June 2018 | Science
  • The End of AIDS: Far from Over

    The tools exist. HIV/AIDS can be treated and contained. But in many communities, social, political and economic obstacles get in the way. There, the epidemic is far from over. PBS Newshour reports from Russian, Nigeria and Florida.

    12 June 2018 | PBS NewsHour
  • FDA says Prezcobix should not be given to pregnant women

    Darunavir/cobicistat — marketed as Prezcobix (Janssen) in the United States — should not be given to pregnant women with HIV because of substantially lower exposures of the two medications during pregnancy, the FDA said. The agency updated the label for the once-daily, fixed-dose tablet to reflect the change, which it said was based on data from a small clinical trial involving pregnant women.

    11 June 2018 | Healio (requires free registration)
  • Irish mums diagnosed with HIV worry more about how diagnosis will affect family than themselves, study finds

    Aside from worrying about passing HIV on, these mothers tend to prioritise the needs of the family at the expense of their own healthcare on a day-to-day basis

    08 May 2018 | Irish Mirror
  • Anti-HIV drug combination does not increase preterm birth risk, study suggests

    A drug combination aimed at preventing transmission of HIV from a pregnant woman to her fetus likely does not increase the risk for preterm birth and early infant death, according to a re-analysis of two studies funded by the National Institutes of Health. The research appears in the New England Journal of Medicine.

    26 April 2018 | National Institutes of Health
  • Giving birth has become less dangerous in South Africa

    The main reason for South Africa’s decline in maternal death ratios, according to the SAMJ study, is the “large-scale reduction in deaths owing to HIV infection as a result of the success of the HIV antiviral treatment programme in pregnancy and beyond”.

    04 April 2018 | Bhekisisa
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