Microbicides are products that are still being researched which could be used in the vagina and/or rectum to reduce the risk of HIV infection. They work in a similar way to oral PrEP, but come in the form of gels, douches and vaginal rings.

Microbicides: latest news

Microbicides resources

  • Microbicides

    Microbicides are any substances which protect people against infection by microbes, such as viruses or bacteria, on contact with those microbes....

    From: Preventing HIV

    Information level Level 4
  • Microbicides

    A microbicide is a topical agent that, when applied to a mucosal surface, serves as a barrier to infection. Microbicides can come in the form of...

    From: HIV transmission & testing

    Information level Level 4

Microbicides features

Microbicides news from aidsmap

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Microbicides news selected from other sources

  • Emerging options: Doctors and advocates discuss treatment and prevention breakthroughs on the horizon

    Long-acting injectables, implantables, the dapivirine ring, vaccines, antibodies, rectal douches, and two-drug regimens.

    30 January 2019 | Positively Aware
  • Making Clinical Trials of PrEP More Inclusive of Women, No Matter Their Pregnancy Status

    Three new trials of HIV prevention drugs seek to answer directly a question that researchers inside and outside the field of HIV have explicitly avoided for years: How do drugs work -- and are they safe -- in pregnant and breastfeeding women?

    01 October 2018 | The Body Pro
  • First Multipurpose Gel Designed to Prevent HIV, HSV, and HPV Simultaneously in Women and Men Advances in Clinical Trials

    A new Phase I study of the Population Council’s multipurpose prevention technology (MPT) gel PC-1005, launching this week, will examine the safety of the gel when used rectally by both men and women. If proven effective, PC-1005 gel would be the first product to prevent three incurable sexually transmitted infections (STIs)—HIV, herpes simplex virus (HSV), and human papillomavirus (HPV)—when used either vaginally or rectally.

    25 June 2018 | Population Council
  • Vaginal implant might stop HIV transmission

    Scientists at the University of Waterloo have developed a promising new medical device that could help protect women from HIV. The technology consists of a vaginal implant that basically reduces the amount of targets the virus can latch onto during sex, and may prove a more effective measure than some anti-HIV drugs or condoms in fending off infections.

    17 April 2018 | New Atlas
  • CROI 2018: Highlights and what’s next for advocates

    Historically, CROI is heavy on basic science and early-phase research. Data from these types of studies were still prominent in 2018, but this year the meeting also broadened its lens from the lab to the ways that different strategies are, or might, have an impact in the context of people's complex lives.

    27 March 2018 | AVAC
  • In the Era of Daily PrEP, Feds May Stop Research Funding Gels, Rings, and Douches for HIV Prevention

    It's precisely because of the overwhelming success in recent years of oral PrEP that the future of the anal douche and other sorts of topically applied anti-HIV agents, such as gels and dissolvable films, all loosely termed "microbicides," is suddenly up in the air, if not outright doomed.

    07 March 2018 | The Body
  • Genital inflammation reduces efficacy of tenofovir gel against HIV in women

    The researchers performed a post hoc prospective analysis of 774 patients who participated in the Centre for the AIDS Program of Research In South Africa (CAPRISA) 004 study, a trial of topical tenofovir gel. McKinnon and colleagues measured concentrations of nine different proinflammatory cytokines from cervicovaginal lavages, and defined genital inflammation using a graduated cytokine store.

    28 February 2018 | Healio
  • Do HIV-Preventing Microbicides Have a Future in the Age of PrEP?

    Courting controversy, the NIH considers a shift away from the development of new vaginal or rectal-based HIV prevention products.

    11 December 2017 | Poz
  • Vital Microbicides May Soon Be Out of Reach

    Whether, when, and how microbicide development proceeds depends on the U.S government, and the federal Division of AIDS has suggested this development may no longer be a priority. It's wrong.

    10 November 2017 | Rewire
  • DAIDS Boss Muses on the Future of HIV Prevention Research

    Below are some of Dr. Dieffenbach’s rather intentionally provocative ideas about specific HIV prevention research candidates—challenges and promises, and the questions they may raise for the next clinical trial research network structure.

    20 October 2017 | AVAC
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