Direct-acting antivirals bring fewer HCV-related liver transplants, better survival after transplantation, in Europe
There has been a steep fall in the number of hepatitis C virus (HCV)-related liver transplants since the introduction of direct-acting antivirals (DAAs), according to European research presented to the 2018 International Liver Congress in Paris. The decline was especially evident in people with HCV-related decompensated cirrhosis. Survival among people with HCV receiving a new liver also improved dramatically.
Eight weeks of treatment with Epclusa cured almost all people with HCV receiving opioid substitution therapy
An eight-week course of sofosbuvir/velpatasvir (Epclusa) cured almost all people with hepatitis C genotype 3 without cirrhosis receiving treatment alongside opioid substitution therapy through community pharmacies or prisons in the Greater Glasgow area, Alison Boyle of Gartnavel Hospital, Glasgow, reported at the conference.
The combination of sofosbuvir and the new NS5A inhibitor ravidasvir cured 97% of people with hepatitis C in a study carried out in Malaysia, and could provide a safe and effective cure for hepatitis C in low- and middle-income countries for $300 or less, researchers of the Drugs for Neglected Diseases Initiative reported on the opening day of the conference.