The risk of several cancers increases with age for older HIV-positive people, investigators from the United States report in Clinical Infectious Diseases. HIV-positive individuals aged 50 and over had a significantly higher incidence of numerous cancers, including several not normally considered HIV-related.
HIV-positive women starting antiretrovirals before conception have increased risk of having an infant that is small for gestational age
HIV-positive women who take combination antiretroviral therapy (cART) before conception have an increased risk of having a small for gestational age (SGA) baby, according to Dutch research published in PLOS One. Overall, HIV therapy before conception increased the risk of having an SGA infant by approximately a third. But the risk was only significant if the pre-conception regimen was based on a protease inhibitor (PI).
Elimination of hepatitis C among people who inject drugs in Europe will require simultaneous scale-up of direct-acting antiviral treatment, needle and syringe programmes (NSP) and opioid substitution treatment (OST), and a re-think of attitudes to drug policy and harm reduction in Central Europe, according to a modelling study led by researchers from the University of Bristol.
NHS England announced this week that it aims to eliminate hepatitis C by 2025 – if it can negotiate 'best value for money' deals with the pharmaceutical industry in a new round of tendering for direct-acting antivirals due to take place in February.
A history of treatment with some older antiretroviral drugs can have a lasting negative impact on liver health, German researchers report in PLOS One. They found that although co-infection with hepatitis C virus (HCV) was the strongest risk factor for liver damage, treatment with didanosine (ddI) and zidovudine (AZT) was also associated with significant liver fibrosis or cirrhosis. Neither of these drugs is now used in routine HIV care, and the study found strong evidence that viral suppression with antiretroviral therapy halved the risk of liver fibrosis in those previously exposed to the drugs.
The majority of HIV-positive women diagnosed with gynaecological cancer do not receive treatment recommended by cancer guidelines, according to research conducted in the United States and published in AIDS. Women whose care did not match guideline standards had poorer survival compared to women who received the recommended care. Toxicity and patient factors were the main reasons why women did not receive treatment recommended in guidelines.
Despite numerous risk factors for HIV, a high proportion of Malawian adolescent girls and young women don't see themselves at risk
Many adolescent girls and young women with multiple risk factors for infection with HIV do not consider themselves to be at high risk for acquiring the infection or worry about HIV, according to research conducted in Malawi and published in the Journal of Acquired Immune Deficiency Syndromes.
Less than half of adolescent girls and young women with HIV have suppressed viral load in eastern and southern Africa
Less than half of adolescent girls and young women with HIV in some of the countries with the highest burden of HIV in sub-Saharan Africa have a fully suppressed viral load on antiretroviral treatment, well below the average for the population as a whole, findings from national surveys published in Mortality and Morbidity Weekly Reports show.