In the face of extensive research showing that people living with HIV who are on antiretroviral therapy (ART) with stable undetectable viral load have an extremely low likelihood of transmitting the virus, a majority of participants at IDWeek 2016 in New Orleans thought they should still be advised to use condoms – a proportion that actually increased after a debate that laid out the evidence.
Tenofovir alafenamide works well and improves kidney and bone markers in older people living with HIV
A co-formulation of tenofovir alafenamide (TAF) plus emtricitabine, used with a third antiretroviral drug, maintained viral suppression as well as tenofovir disoproxil fumarate (TDF) plus emtricitabine in older individuals, and was associated with improvements in kidney function and bone density, which may be of greater concern for this group, according to a presentation at the conference.
Long-term use of omega-3 fatty acid supplements was associated with reduced levels of triglycerides and the inflammation biomarker C-reactive protein (CRP) in HIV-positive people with suppressed viral load, according to research presented at the conference.
A once-daily regimen containing the potent HIV integrase inhibitor dolutegravir worked better than an older atazanavir-containing regimen – with higher rates of viral suppression both overall and across race subgroups – in the ARIA trial, one of the few antiretroviral therapy studies to enrol only women, according to a presentation at the conference.
Ibalizumab, an experimental monoclonal antibody with a unique mechanism of action, demonstrated good safety and promising efficacy in a small phase 3 study of people with extensive drug resistance who cannot be successfully treated with available therapies, according to a report at the conference.
Rates of gonorrhoea, syphilis and chlamydia have risen steeply at Fenway Health in Boston since 2011, according to a presentation at the conference. Being HIV-positive men and using pre-exposure prophylaxis (PrEP) to prevent HIV were associated with higher risk of getting sexually transmitted infections (STIs), but more frequent STI testing and treatment could potentially help reduce the numbers.
A machine learning algorithm used to analyse electronic health records (EHRs) identified high-risk individuals who could potentially benefit from HIV pre-exposure prophylaxis (PrEP), according to a report presented at the conference. Out of 800,000 patients in a large EHR database, more that 8000 were found to be potential PrEP candidates.