New NNRTI MK-1439 shows promise in early clinical trial

Published: 06 March 2013
Matt Anderson at CROI 2013. © Liz Highleyman / hivandhepatitis.com

A next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), MK-1439, demonstrated robust antiretroviral activity and good tolerability as monotherapy in a small phase Ib clinical study, researchers reported yesterday at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) in Atlanta.

NNRTIs are generally well tolerated and are well-suited for first-line HIV treatment, but as a class these drugs are susceptible to resistance. Pre-clinical studies showed that MK-1439 has enhanced activity against HIV strains with certain other common NNRTI resistance mutations (including K103N and Y181C). Unlike the widely used NNRTI efavirenz (Sustiva or Stocrin), it appears to have low potential for central nervous system (CNS) toxicity.

Matt Anderson from Merck and colleagues evaluated MK-1439 in a double-blind, placebo-controlled trial at a single site in Berlin. The researchers looked at drug safety, tolerability, antiviral activity, pharmacokinetics and emergence of viral resistance.

This study was the first to test multiple doses of MK-1439 in HIV-positive people. Prior research showed acceptable safety and pharmacokinetics in HIV-negative volunteers (also reported at CROI, poster 527) and in HIV-positive people given single doses up to 1200mg.

This analysis included 18 previously untreated people with HIV. Although both men and women were eligible, only men sought to enrol in the trial. Ages ranged from 23 to 45 years. At study entry they had at CD4 cell counts of at least 200 cells/mm3 and normal biochemistry and blood lab results. People with hepatitis B or C co-infection were excluded.

Participants were evenly randomised to receive 25mg or 200mg once-daily MK-1439 or placebo as monotherapy for seven days. After completion of dosing, participants were started on standard combination antiretroviral therapy for ten more days so that residual MK-1439 would not promote development of resistance in the absence of other antiretrovirals.

MK-1439 showed potent antiviral activity. Viral load levels fell steadily for people taking either dose of MK-1439, whilst remaining stable for placebo recipients. At day seven of treatment, HIV RNA declines were similar in the 25mg and 200mg dose arms, at 1.37log10 and 1.26 log10, respectively. No participants showed evidence of viral breakthrough after one week of monotherapy.

MK-1439 pharmacokinetic parameters were similar to those previously seen in HIV-negative volunteers taking the same doses. Drug levels reached a steady state after three to five days, exposures exceeded the level needed for viral inhibition, and the average effective half-life in the body was 10 to 16 hours.

MK-1439 continued to appear safe and well tolerated. Although about three-quarters of participants experienced adverse events, these were mostly mild-to-moderate in intensity and resolved after the end of treatment. No significant skin rash, CNS events or laboratory abnormalities were reported.

Only three events were considered potentially related to the drug (night sweats, headache, and loss of appetite). The single serious adverse event – increased liver enzymes in a person with acute hepatitis C – was judged to be probably unrelated to the study drug.

"MK-1439 was generally well tolerated with no clinically significant trends or signals apparent in vital sign measurements, laboratory findings, or ECGs," the researchers concluded. "Similarly robust antiviral activity against HIV-1 was observed with 25 and 200mg QD [once-daily] doses."

Anderson said that a phase IIb clinical trial is currently enrolling to compare MK-1439 and efavirenz, both with tenofovir/emtricitabine (the drugs in Truvada). More details are available at www.clinicaltrials.gov/ct2/show/NCT01632345.

Reference

Anderson M et al. Safety and antiviral activity of MK-1439, a novel NNRTI, in treatment-naive HIV+ patients. 20th Conference on Retroviruses and Opportunistic Infections, Atlanta, abstract 100, 2013.

View abstract 100 on the conference website.

Anderson M et al. Safety, tolerability, and pharmacokinetics of single and multiple doses of MK-1439, a novel HIV NNRTI, in healthy subjects. 20th Conference on Retroviruses and Opportunistic Infections, Atlanta, abstract 527, 2013.

View abstract 527 on the conference website.

A webcast of the session in which this research was presented, ART: new agents and new insights, is available on the conference website.

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NAM is partnering with gTt (Barcelona), GAT (Lisbon) and LILA (Como) to deliver the CROI 2013 bulletins, which have also been made possible thanks to support from Bristol-Myers Squibb. NAM’s wider conference news reporting services have been supported by Abbott, Boehringer Ingelheim, Janssen, Roche and ViiV Healthcare. The funders have no editorial control over the content of the materials.