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New analysis of old HIV vaccines finds potentially protective immune response

Applying the benefit of hindsight, researchers have reanalyzed the findings of two historic pediatric HIV vaccine trials with encouraging results. The vaccines had in fact triggered an antibody response -- now known to be associated with protection in adults -- that was previously unrecognized in the infants studied in the 1990s.

Published
01 September 2014
From
Science Daily
HIV Antibodies Block Infection by Reservoir-Derived Virus in Laboratory Study

The researchers conclude that passive immunotherapy involving bNAbs individually or in combination may control HIV in the absence of antiretroviral therapy. A number of clinical trials are already underway or planned to test this hypothesis.

Published
27 August 2014
From
National Institutes of Allergy and Infectious Diseases press release
Novel immune-suppressant vaccine completely blocks HIV infection in monkeys: human trials planned

A novel and relatively simple vaccine that can be administered orally has managed to completely block rectal infection with SIV, the monkey equivalent of HIV, in rhesus

Published
26 August 2014
By
Gus Cairns
Mechanism found for development of protective HIV antibodies

Scientists have found an immunologic mechanism that makes broadly neutralizing antibodies in people who are HIV-1 infected. The research team found that two distinct B-cell lineage antibodies teamed up to stimulate the highly sought-after broadly neutralizing antibodies to HIV. The induction of these antibodies that can neutralize a variety of HIV strains is a key strategy for a global vaccine, they say.

Published
22 August 2014
From
Science Daily
HIV, HCV and TB Pipeline Report

Drugs, diagnostics, vaccines, preventive technologies, research towards a cure, and immune-based and gene therapies in development.

Published
21 July 2014
From
Treatment Action Group & i-Base
Researcher Admits to HIV Vaccine Fraud

United States prosecutors have filed charges against a researcher who admitted to fraudulently reporting data while conducting research for a HIV vaccine. Dong-Pyou Han, a former laboratory manager at Iowa State University, admitted to putting human antibodies into samples of rabbit’s blood to create the illusion that an experimental vaccine was potentially effective. After millions in grants from the National Institutes of Health and years of work, another laboratory discovered irregularities that showed the results were false.

Published
26 June 2014
From
Guardian Liberty Voice
Researchers trace HIV adaptation to its human host

In a new study that traces the evolution of HIV in North America, researchers have found evidence that the virus is slowly adapting over time to its human hosts. However, this change is so gradual that it is unlikely to have an impact on vaccine design.

Published
11 June 2014
From
Science Daily
Scripps Research Institute Scientists Find New Point of Attack on HIV for Vaccine Development

A team led by scientists at The Scripps Research Institute (TSRI) working with the International AIDS Vaccine Initiative (IAVI) has discovered a new vulnerable site on the HIV virus. The newly identified site can be attacked by human antibodies in a way that neutralizes the infectivity of a wide variety of HIV strains.

Published
28 April 2014
From
Scripps Research Institute
UK academic: HIV vaccine research 'to reach defining moment' by 2020

A leading academic predicts the next six years will determine whether developing an effective HIV vaccine is within the grasp of scientists.

Published
05 April 2014
From
PinkNews.co.uk
Crowdfunded free HIV vaccine: as unlikely as it sounds

Are the claims of a research start-up that is seeking to crowd-fund HIV vaccine research credible?

Published
17 February 2014
From
Wired
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