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Lancet: Phase 2b trial results of novel TB regimen show potential to shorten treatment

A new tuberculosis (TB) drug regimen designed to improve options for TB therapy eliminated more bacteria from sputum than standard therapy, worked for people with multi-drug-resistant (MDR) TB, and did so in a quarter of the time, according to data from a phase 2b clinical trial published today in The Lancet. These results are published just as the global phase 3 clinical trial, STAND, designed to bring this regimen through the last stage of testing, has begun. The PaMZ regimen uses pretomanid, a new drug; moxifloxacin, an established antibiotic that is experimental as a TB treatment; and pyrazinamide, an established TB drug. Twenty percent of the TB patients enrolled in NC-002 also were co-infected with HIV and the PaMZ regimen appeared to be effective independent of HIV status. See also http://www.aidsmap.com/Novel-TB-regimen-could-reduce-treatment-duration/page/2892700/

Published
18 March 2015
From
Lancet (free registration required)
Tuberculosis and superbug strains 'ravaging' Europe, WHO warns

As many as 1,000 people a day in Europe contract tuberculosis, and slow progress against the disease coupled with rising drug resistance mean the region is unlikely to defeat it until next century, health officials said on Tuesday.

Published
17 March 2015
From
Reuters
TB/HIV Research Frontiers Meeting in conjunction with the 22nd Conference on Retroviruses and Opportunistic Infections (CROI 2015)

The objective of the meeting was to discuss and promote high level scientific interchange on ideas and updates about ongoing clinical trials on empirical TB treatment for preventing early mortality in people living with HIV and assess their eventual impact on policy change. The meeting also discussed the prospect of using rifamycins for prevention of tuberculosis in resource limited settings with high TB and HIV prevalence.

Published
05 March 2015
From
World Health Organization
CROI 2015: Trial to evaluate the use of health navigators to link HIV/TB patients to care and treatment fails to show positive results

Patients randomized to the support of a health navigator were not more likely than those who received standard of care to complete tuberculosis treatment or begin antiretroviral therapy within three months of HIV diagnosis, according to the results of a South African randomized trial presented here today.

Published
26 February 2015
From
Science Speaks
Starting HIV treatment at CD4 count above 500 reduces the risk of serious illness and death by 44%, African Temprano trial shows

Starting HIV treatment at a CD4 cell count above 500 reduced the risk of serious illness including tuberculosis (TB), and death, by 44% when compared to starting

Published
26 February 2015
By
Keith Alcorn
XDR-TB in South Africa is largely spread person-to-person, not by failure of drug treatment

The vast majority of people with extensively drug-resistant tuberculosis (XDR-TB) diagnosed in the world’s most extensive outbreak have acquired their infection from another person, not as the

Published
26 February 2015
By
Keith Alcorn
UGA researchers discover potential treatment for drug-resistant tuberculosis

The compound Nair and his colleagues developed works by binding to magnesium and specific amino acids found within the bacterium, interrupting the production of RNA. They were surprised to discover through preliminary experiments that it also exhibited strong anti-HIV properties, opening the door for dual therapeutic applications.

Published
20 February 2015
From
University of Georgia press release
TB drug candidate starts Phase 1 trial — first in six years

The enrollment of nearly 50 volunteers in the United States will launch the first randomized clinical trial of a potential  new drug to treat TB in six years, the nonprofit product development partnership TB Alliance announced Wednesday.

Published
20 February 2015
From
Science Speaks
Fighting tuberculosis in the European region requires urgent support. Take action today!

Today, the TB Europe Coalition, with the support of Stop TB Partnership, launches the Fight TB 2015 campaign to ensure that European leaders step up their response to TB to save millions of lives.

Published
18 February 2015
From
TB Europe Coalition
South Africa: Pledge to turn tide in the war on TB

A massive tuberculosis screening programme to the tune of half a billion rand will begin next month, covering three areas of society most vulnerable to the disease, Health Minister Aaron Motsoaledi said yesterday at a briefing held in Pretoria. Every prisoner in the country will be screened for tuberculosis from next month. If inmates test positive, their families will be tracked and also tested for the disease. There are over 150,000 prisoners in South Africa.

Published
17 February 2015
From
Times Live

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