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South Africa: Bedaquiline approved to treat multi-drug resistant tuberculosis

The Medicines Control Council has approved Janssen Pharmaceutica's bedaquiline, the first drug specifically designed for treating multi-drug resistant tuberculosis (MDR-TB) to reach the market. Janssen is a subsidiary of Johnson & Johnson.

Published
19 hours ago
From
Business Day
Newly identified marker helps predict tuberculosis complications in HIV patients

An NIAID study suggests that the increased frequency of an immune cell called CD14++CD16- monocyte is a strong indicator that a patient with HIV and tuberculosis (TB) may develop immune reconstitution inflammatory syndrome (IRIS).

Published
16 October 2014
From
National Institute of Allergy and Infectious Diseases (NIAID) press release
Isoniazid significantly reduced TB incidence in HIV patients receiving HAART

The use of isoniazid as preventive therapy among HIV-infected patients receiving highly active antiretroviral therapy (HAART) is associated with significantly lower tuberculosis incidence, reported Bethel Shiferaw, MD, MPH, from Nassau University Medical Center, East Meadow, at IDWeek 2014.

Published
16 October 2014
From
Monthly Prescribing Reference (MPR)
In HIV/TB coinfection, initiate antiretroviral therapy early

Earlier initiation of antiretroviral therapy (ART) significantly lowered mortality in patients with HIV and tuberculosis (TB) co-infection, despite a higher incidence of immune reconstitution inflammatory syndrome (IRIS), according to data presented at 2014 IDWeek.

Published
16 October 2014
From
Monthly Prescribing Reference (MPR)
UNITAID: Tuberculosis diagnostics technology and market landscape – 3rd edition

UNITAID releases today its 2014 Tuberculosis Diagnostics Technology and Market Landscape, detailing the promising pipeline of products and technologies to diagnose tuberculosis (TB). The report highlights current and emerging technologies from over 80 manufacturers and developers, including products which are smaller, simpler and easier to use.

Published
01 October 2014
From
EATG
Minsk has extremely high levels of drug-resistant TB, a study in Belarus reveals

Multidrug-resistant (MDR)-TB was found in 35.3% (95% CI 27.7–42.8) of new patients and 76.5% (95% CI 66.1–86.8) of those previously treated. Overall, nearly one in two patients enrolled had MDR-TB. Extensively drug-resistant TB was reported in 15 of the 107 MDR-TB patients (14.0%, 95% CI 7.3–20.7). The findings of this survey in Minsk city are alarming and represent the highest proportions of MDR-TB ever recorded in the world.

Published
29 September 2014
From
TB Europe Coalition
What does new drug PaMZ mean for TB and HIV treatment?

The development of PaMZ has been hailed as a breakthrough. But what do the experts think?

Published
02 September 2014
From
The Guardian
Acquired rifampicin resistance more likely in HIV-coinfected patients

Patients with HIV and tuberculosis were more likely to develop acquired rifampicin resistance when treated with a thrice-weekly tuberculosis treatment compared with patients not coinfected with HIV, according to researchers from the National Institute for Research in Tuberculosis in India. The rate of bacteriologic failure was 4% among patients without HIV. Among patients with HIV, the rates were 9% for those not receiving ART and 5% for those receiving ART.

Published
02 September 2014
From
Healio
TB Epidemic Threat Hangs Over Ukraine Conflict

Doctors are warning of a worsening tuberculosis epidemic in Eastern Ukraine as the continuing conflict there begins to take a heavy toll on public health. With thousands of people fleeing the region every day, medical supplies severely disrupted and those left behind under growing physical stress and increasingly unable to access medical services, conditions are ripe for a rise in new TB cases.

Published
20 August 2014
From
InterPress Service
Use of drug susceptibility testing to select therapy improves treatment outcomes in patients with MDR- and XDR-TB

New research published in the online edition of Clinical Infectious Diseases supports World Health Organization (WHO) recommendations for the use of drug susceptibility testing to select drugs for the

Published
13 August 2014
By
Michael Carter
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