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US: TB programs affected by isoniazid shortage

A shortage of isoniazid interfered with patient care and may contribute to the spread of tuberculosis in the United States, according to a report by the CDC. “Interruptions in the supply of second-line anti-TB medications have been ongoing in the United States for several years,” the researchers wrote in Morbidity and Mortality Weekly Report. “But since November 2012, TB control programs have experienced the first sustained generalized supply interruption of a first-line anti-TB medication.”

Published
24 May 2013
From
Healio
Study finds vitamin C can kill drug-resistant TB in test-tube

In a striking, unexpected discovery, researchers at Albert Einstein College of Medicine of Yeshiva University have determined that vitamin C kills drug-resistant tuberculosis bacteria in laboratory culture. The finding suggests that vitamin C added to existing TB drugs could shorten TB therapy, and it highlights a new area for drug design. The study was published today in the online journal Nature Communications.

Published
22 May 2013
From
Eurekalert Inf Dis
Book Review: The Plague That Refuses to Go Away

Jasmine Grenier and Madhukar Pai from McGill University review “Spitting Blood: The History of Tuberculosis” by Helen Bynum.

Published
16 May 2013
From
PLoS Blogs (blog)
Portable device provides rapid, accurate diagnosis of tuberculosis, other bacterial infections

A handheld diagnostic device that Massachusetts General Hospital (MGH) investigators first developed to diagnose cancer has been adapted to rapidly diagnose tuberculosis (TB) and other important infectious bacteria.

Published
07 May 2013
From
Eurekalert (press relesae)
The ongoing problem of tuberculosis in the UK

The report of the All-Party Group on Global Tuberculosis gives grounds for optimism; although the task is huge it provides a coherent set of recommendations that can be taken on by a new public health body seeking to demonstrate its leadership and effectiveness. Successfully leading the strategy to eliminate tuberculosis in the UK should be an agreed metric to measure the performance of Public Health England.

Published
26 April 2013
From
The Lancet (editorial)
Researchers make a significant step forward in combating antibiotic resistance

Antibiotic resistance is a global problem. The World Health Organisation (WHO) estimates that for tuberculosis alone multi-drug resistance accounts for more than 150,000 deaths each year. Now researchers are one step closer to understanding why antibiotics are ineffective against certain types of bacteria.

Published
25 April 2013
From
Durham University News
Drug-Resistant Tuberculosis: Old Disease – New Threat

In a new Report a group of MPs is calling on the UK Government for a two-fold approach to tackling the increasing public health threat of tuberculosis (TB) which is being exacerbated by drug-resistant strains (DR-TB) in all parts of the world, including the UK.

Published
15 April 2013
From
UK All-Party Parliamentary Group on Global Tuberculosis
Tuberculosis prevention may speed drug resistance

According to the new study, led by Harriet Mills at the University of Bristol, in communities that implement isoniazid preventive therapy (IPT), the incidence of new isoniazid-resistant cases per year will double in the next 40 years.

Published
15 April 2013
From
Nature
Rifapentine’s manufacturer helps to advance TB research while stalling access

Sanofi-Aventis, manufacturer of the tuberculosis (TB) drug rifapentine (Priftin), can be credited for aiding research efforts to shorten and simplify treatment dosing for TB. However, the company’s pricing of the drug has hampered access to such regimens, even in resource-rich nations like the United States.

Published
12 April 2013
From
Treatment Action Group
Significant Declines in TB Incidence, Prevalence and Mortality, but MDR-TB Remains a Threat

TB mortality has decreased significantly since 2000 and treatment success rates have shown steady improvement. More than half of the countries that have received Global Fund support are on track to meet the international targets for case detection, treatment success, and TB disease incidence. However, multi-drug-resistant TB (MDR-TB) remains a critical threat.

Published
09 April 2013
From
Global Fund Observer
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