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Resistance
Computer models predict how patients will respond to HIV drugs

Results of a new study demonstrate that computer models can predict how HIV patients whose drug therapy is failing will respond to a new treatment. Crucially for patients in poorer countries, the models do not require the results of expensive drug resistance tests to make their predictions. The study also showed that the models were able to identify alternative drug combinations that were predicted to work in cases where the treatment used in the clinic had failed, suggesting that their use could avoid treatment failure.

Published
14 March 2013
From
Eurekalert Inf Dis
Resistance
Wide US Study Finds 16% With Newly Diagnosed HIV Carry Resistant Virus

Just over 16% of US residents newly diagnosed with HIV infection in 10 metropolitan areas or states carried antiretroviral-resistant virus, according to a CDC study spanning the years 2007 to 2010.

Published
11 March 2013
From
NATAP
Treatment-experienced people
New integrase inhibitor dolutegravir helps treatment-experienced people on failing therapy

The next-generation integrase inhibitor dolutegravir proved more beneficial than raltegravir (Isentress) for treatment-experienced people with resistance to two or more antiretroviral drug classes, researchers reported in a poster

Published
10 March 2013
By
Liz Highleyman
New and experimental HIV treatments
Can people with resistant HIV omit NRTIs when switching from a failing regimen?

Omitting nucleoside reverse transcriptase inhibitors (NRTIs) when switching from a non-suppressive regimen to a new combination with at least two active agents can reduce pill burden and

Published
07 March 2013
By
Liz Highleyman
Resistance
Transmission of Resistant HIV Steady

The rate of drug-resistant HIV transmission in the U.S. appears to be holding steady, according to the most recent CDC figures.

Published
07 March 2013
From
MedPage Today HIV/AIDS
Treatment guidelines
Updated HIV Treatment Guidelines Include Stronger Recommendation for Acute Infection

Among the key changes are additional information about the most recently approved antiretroviral agents and a recommendation that newly infected people with HIV should be offered combination ART. The guidelines continue to recommend treatment for all people with HIV, both to reduce the risk of disease progressionand for the prevention of HIV transmission.

Published
15 February 2013
From
HIVandHepatitis.com
Treatment guidelines
Updated U.S. DHHS guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents

New recommendations on drug-resistance testing, genotypic tropism assays, starting treatment, acute infection, pregnancy and interactions.

Published
15 February 2013
From
AIDSinfo
Resistance
Nigeria: Drug resistance data show merits of using tenofovir in first-line ART regimens

People living with HIV in Nigeria, at high risk for virological failure, on a tenofovir (TDF)-based first-line regimen, had fewer nucleoside reverse transcriptase inhibitor (NRTI) drug-resistant mutations

Published
23 January 2013
By
Carole Leach-Lemens
Resistance
Prevalence of drug-resistant HIV has fallen dramatically among antiretroviral-experienced patients in Western Europe

There has been a significant fall in the proportion of HIV-positive people in Western Europe with experience of HIV treatment who have resistance to antiretroviral

Published
22 January 2013
By
Michael Carter
Treatment-experienced people
Any reduction in viral load has immunologic benefits for people with HIV who have triple-class treatment failure

HIV therapy that achieves even modest reductions in viral load can have profound immunological benefits for people with triple-class treatment failure, European investigators report in the online edition

Published
08 January 2013
By
Michael Carter
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