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Drug-resistant infections could lead to 10 million extra deaths a year – report

The stark figures, published on Thursday, and believed to be the first to quantify the potential impact of antimicrobial resistance (AMR) – drug-resistant infections or superbugs – will be used to make the case to global leaders that urgent action is needed. To put the figures in context there are currently 8.2 million deaths a year from cancer and annual global GDP stands at $70tn to $75tn, with the UK figure around $3tn.

Published
11 December 2014
From
The Guardian
What are the barriers that could stop HIV treatment becoming HIV prevention?

One of the key strategies involved in trying to bring an end to the HIV epidemic is to increase the proportion of HIV-positive people on antiretroviral therapy

Published
12 November 2014
By
Gus Cairns
Protease inhibitor monotherapy: darunavir/ritonavir less effective than three-drug therapy

Darunavir/ritonavir monotherapy results in a lower rate of viral suppression after 48 weeks when compared to darunavir/ritonavir plus two nucleoside reverse transcriptase inhibitors (NRTIs), but may

Published
07 November 2014
By
Keith Alcorn
Injectable rilpivirine shows promise in phase I trials – but may work better for anal than vaginal sex

A phase one dose-finding and safety study in humans of TMC278 LA, a long-acting, injectable formation of the antiretroviral (ARV) drug rilpivirine, found that a single

Published
01 November 2014
By
Gus Cairns
Emerging epidemic of transmitted HIV drug resistance in low- and middle-income countries, with highest burden seen in MSM

Prevalence of transmitted drug-resistant HIV has doubled in low- and middle-income countries in recent years, results of a meta-analysis published in AIDS show. Between 2004-08 and 2009-13,

Published
28 October 2014
By
Michael Carter
Longer time to virological failure and less drug resistance seen in people taking Atripla than in people taking separate drugs

An analysis of people who experienced treatment failure on their first-line HIV therapy with a viral load of over 400 copies/ml and who had taken either

Published
09 September 2014
By
Gus Cairns
Dolutegravir demonstrates good efficacy despite resistance

Antiretroviral regimens containing the recently approved HIV integrase inhibitor dolutegravir (Tivicay) demonstrated high rates of viral suppression even in treatment-experienced people who had virus with resistance to

Published
24 July 2014
By
Liz Highleyman
High rates of drug resistance among HIV-positive infants in South Africa

There was a high prevalence of antiretroviral drug resistance among infants newly diagnosed with HIV in Johannesburg, investigators report in AIDS. Over half the infants

Published
13 July 2014
By
Michael Carter
People starting therapy on a boosted protease inhibitor don't need to switch after one virological failure episode, study indicates

Remaining on the same regimen is a “reasonable” strategy for people taking first-line antiretroviral therapy (ART) based on a ritonavir-boosted protease inhibitor who experience virologic failure, according to

Published
09 June 2014
By
Michael Carter
An activist's guide to TB drugs

TB treatment must be shorter, simpler, less toxic, and more tolerable and affordable. Activists can contribute to the development and uptake of improved TB treatment by calling attention to research, quality of medications, and access priorities.

Published
04 June 2014
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