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Outbreak of high level azithromycin resistant gonorrhoea in England

There have been 34 cases of high level azithromycin resistant gonorrhoea amongst residents of England between November 2014 and April 2016. The outbreak spread from the north of England to the West Midlands and south of England, including London. Initial cases were among heterosexuals but more recent evidence suggests high level azithromycin resistant gonorrhoea is now spreading among men who have sex with men.

Published
15 April 2016
From
Public Health England
Resistance to anti-HIV drugs in steep decline in Switzerland

Prevalence of antiretroviral drug resistance has declined significantly among patients in Switzerland, investigators report in the online edition of Clinical Infectious Diseases. As many as 57% of

Published
13 April 2016
By
Michael Carter
Nigerian herbal medicines widely used by HIV positive people can contain antiretrovirals

Herbal medicine use among HIV positive people in Nigeria is widespread, poorly recorded and often precedes ART initiation. Contamination with antiretrovirals is possible and concerning, particularly in untreated people, say the authors of a study of herbal medicine presented at CROI 2016.

Published
24 March 2016
From
HIV i-Base
Combination inhibitor BMS-986197 demonstrates good activity against HIV in early study

A long-acting bio-engineered molecule with a triple mechanism of action demonstrated potent antiviral activity and worked against HIV that developed resistance to any one of the three

Published
18 March 2016
By
Liz Highleyman
Dr. Robert Grant weighs in after the first case of failed PrEP: What does it mean?

At CROI today, researchers and providers heard a detailed case study of a man who was infected with drug-resistant HIV while taking PrEP. No study to date has definitively documented a “breakthrough” HIV infection during PrEP with adherence to Truvada, so the report has garnered a lot of attention and concern from community members. We spoke with Robert Grant, MD, MPH, to give context to the discussion about what this case means for people currently taking PrEP.

Published
26 February 2016
From
BETA blog
Almost-certain case of PrEP failure due to drug resistance reported at CROI 2016

A case report of a man in Toronto who became infected with a multi-drug-resistant strain of HIV despite apparently very consistent adherence to PrEP was presented at

Published
25 February 2016
By
Gus Cairns
What is a drug “tail,” and what does it have to do with long-acting PrEP?

Drug “tails” are a hot topic at CROI 2016 as attendees wait to hear results from a long-acting cabotegravir PrEP injection study with HIV-negative men. A few prominent researchers have already incorporated the issue of drug “tails” into their discussions of one potential downside to having a PrEP drug that stays in a person’s system for an extended length of time.

Published
25 February 2016
From
BETA blog
HIV and drug resistance

A recent study found more resistance to the antiretroviral medicine tenofovir than had previously been reported, with 20% resistance to tenofovir in patients with treatment failure in Europe and over 50% resistance in patients with treatment failure in sub-Saharan Africa... The study underlines the importance of rapidly identifying treatment failure through routine measurement of viral load suppression—this is the basis of the third pillar of UNAIDS’ 90–90–90 treatment target, that 90% of people accessing HIV treatment have suppressed viral loads.

Published
09 February 2016
From
UNAIDS
Tenofovir resistance may develop in more than half of patients failing treatment in sub-Saharan Africa

More than half of people who experienced failure of a tenofovir-based antiretroviral regimen in sub-Saharan Africa had resistance to tenofovir, a meta-analysis of drug resistance studies published

Published
01 February 2016
By
Keith Alcorn
HIV resistance to favored treatment not uncommon

Resistance to a key HIV drug is common worldwide and could mean trouble for treating and preventing the virus that causes AIDS, according to a new study.

Published
29 January 2016
From
Reuters
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