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Neurological and cognitive problems news

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HIV can spread early, evolve in patients' brains

HIV can genetically evolve and independently replicate in patients' brains early in the illness process, an analysis of cerebral spinal fluid has found. Prompt diagnosis and treatment with antiretroviral therapy should reduce the risk that the virus could find refuge and cause damage in the brain, where some medications are less effective -- potentially enabling it to re-emerge, even after it is suppressed in the periphery, say researchers.

Published
27 March 2015
From
Eurekalert Inf Dis
Screening for cryptococcal meningitis and adherence support reduce mortality among people starting ART in Africa

Screening and treatment for cryptococcal meningitis combined with a short period of adherence support has the potential to significantly reduce mortality rates among people with very low

Published
24 March 2015
By
Michael Carter
Researchers identify key mechanisms underlying HIV-associated cognitive disorders

New findings, published today by researchers at the University of California, San Diego School of Medicine, open the door to the development of new therapies to block or decrease cognitive decline due to HIV-associated neurocognitive disorders, estimated to affect 10 to 50 percent of aging HIV sufferers to some degree.

Published
04 February 2015
From
Medical Xpress
Researchers identify key mechanisms underlying HIV-associated cognitive disorders

New findings, published today by researchers at the University of California, San Diego School of Medicine, open the door to the development of new therapies to block or decrease cognitive decline due to HIV-associated neurocognitive disorders, estimated to affect 10 to 50 percent of aging HIV sufferers to some degree.

Published
04 February 2015
From
Eurekalert Medicine & Health
Antiretroviral Neurotoxicity May Cause Cognitive Problems

As many as 50% of those on combination antiretroviral therapy (cART) suffer from mild to moderate cognitive dysfunction. Antiretroviral medications themselves may be partly to blame for such neurocognitive problems, suggests a recent review of previous studies. But the authors of this review do not recommend that antiretroviral treatment be stopped.

Published
28 January 2015
From
The Body Pro
Elite controllers may pay a high price for their low viral load

About one in 200 people with HIV maintains an undetectable viral load and high CD4 counts without having to take antiretroviral therapy (ART). These so-called ‘elite controllers’

Published
07 January 2015
By
Gus Cairns
Could HIV make hearing worse?

A new study has found that low- and high-frequency hearing is poorer in adults with the human immunodeficiency virus, compared with adults who do not have the disease. Although unexpected, similar hearing loss has previously been observed to be more likely in adults with diabetes mellitus. "It is possible that both HIV infection and diabetes, being systemic diseases, could affect the neural function of the cochlea," the authors suggest.

Published
29 December 2014
From
Medical News Today
Hepatitis C ruled out as cause of mental impairment in HIV patients

“Hepatitis C infection has serious long-term side effects, such as damage to the liver, but our research indicates that it does not affect the brain,” said lead author David Clifford, MD, of Washington University.

Published
15 December 2014
From
Washington University press release
Immune cells proposed as HIV hideout don't last in primate model

The type of immune cell called macrophages, which have been proposed as a 'sanctuary site' of HIV in the brain and other organs, and as a possible cause of HIV-related brain impairment, don't live long enough to serve as reservoirs of HIV, a study in PLoS Pathogens finds.

Published
04 November 2014
From
EATG
HIV RNA lingers in CSF through up to 10 years of suppressive ART

HIV RNA remained detectable at low levels in cerebrospinal fluid (CSF) of almost 20% of patients who had HIV RNA levels below 40 copies/mL for up to 10 years of antiretroviral therapy (ART). The investigators believe their finding indicates that the central nervous system (CNS) can be an HIV reservoir during suppressive ART.

Published
28 October 2014
From
International AIDS Society
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