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Immediate Antiretroviral Therapy Reduces HIV Infection of Resting CD4 T-Cells

Starting antiretroviral therapy (ART) during the acute phase of HIV infection appears to reduce the number of latently infected resting CD4 T-cells in most people, but this may not be the case for individuals with very few initially infected cells, according to a study published in the May 29, 2012, advance online edition of Proceedings of the National Academy of Sciences.

Published
14 June 2012
From
HIVandHepatitis.com
UCSF researchers identify a potential new HIV vaccine/therapy target

After being infected with simian immunodeficiency virus (SIV) in a laboratory study, rhesus macaques that had more of a certain type of immune cell in their gut than others had much lower levels of the virus in their blood, and for six months after infection were better able to control the virus.

Published
31 May 2012
From
Eurekalert Medicine & Health
Researchers discover new HIV-suppressing protein

Scientists have identified a new HIV-suppressing protein in the blood of people infected with the virus. In laboratory studies, the protein, called CXCL4 or PF-4, binds to HIV such that it cannot attach to or enter a human cell.

Published
30 May 2012
From
News-Medical.net
Mechanism of HIV spread has potential for future drug therapy

A new understanding of the initial interactions of human immunodeficiency virus type 1 (HIV-1) and dendritic cells is described by Boston University School of Medicine (BUSM) researchers in a study currently featured in the Proceedings of the National Academy of Sciences (PNAS).

Published
24 April 2012
From
Google Alerts HIV
HIV 'superinfection' boosts immune response: Findings may provide insight into HIV-vaccine development

Women who have been infected by two different strains of HIV from two different sexual partners – a condition known as HIV superinfection – have more potent antibody responses that block the replication of the virus compared to women who’ve only been infected once.

Published
30 March 2012
From
Science Daily
Superinfection: second HIV infections happen as often as first ones

Two studies of people with HIV in Rakai, Uganda and Mombasa, Kenya presented at the 19th Conference on Retroviruses and Opportunistic Infections show that the rate at

Published
10 March 2012
By
Gus Cairns
Deeper view of HIV reveals impact of early mutations

Mutations in HIV that develop during the first few weeks of infection may play a critical role in undermining a successful early immune response, a finding that reveals the importance of vaccines targeting regions of the virus that are less likely to mutate.

Published
09 March 2012
From
Science Daily (press release)
A new patient zero? Researchers may have spotted animal-to-human immunodeficiency virus transfer

A group of scientists working in Ivory Coast may have discovered a case of infection of a human with a novel variety of an animal immunodeficiency virus,

Published
07 March 2012
By
Gus Cairns
Psoriasis Linked to Protection from HIV-1

Many psoriasis patients have the same gene variants as people who are not significantly affected by an HIV-1 infection.

Published
06 March 2012
From
Scientific American
Are HIV Non-Progressors Really Very Slow Progressors?

HIV positive people traditionally classified as long-term non-progressors or viral controllers may in fact progress slowly over time, according to research reported in the February 20, 2012, edition of the open-access journal PLoS ONE. These findings suggest that so-called non-progressors may in fact benefit from antiretroviral therapy and could provide clues to aid in development of immune-based therapies.

Published
27 February 2012
From
HIVandHepatitis.com

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