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HIV Likely Evolved to Enter Latent State Because This Fuels Survival

A pair of new studies suggest that HIV evolved to enter into a latent state in order to thrive in the long run, and that the virus itself, and not infected immune cells, controls when replication stops and starts.

Published
11 hours ago
From
AIDSMeds
Inflammation Persists Despite Very Early HIV Treatment

Biomarkers of inflammation increase during acute HIV infection and remain elevated despite early suppressive antiretroviral therapy, according to a study presented at CROI 2015, in Seattle, Washington.

Published
27 February 2015
From
The Body Pro
Fast-replicating HIV strains drive inflammation and disease progression

The results confirmed the team's previous finding that the replicative capacity of the newly established virus drives how quickly infected individuals' levels of CD4 T cells declined. People infected with viruses with high replicative capacity had more signs of acute inflammation in the first few months of infection. Their T cells displayed more signs of "exhaustion," which sets the stage for faster disease progression.

Published
20 February 2015
From
Emory University press release
Researchers may have caught HIV becoming more virulent

A study from Cuba has generated wide media interest because researchers have identified a particular variety of the virus which is associated with rapid post-diagnosis falls in

Published
19 February 2015
By
Gus Cairns
An aggressive form of HIV uncovered in Cuba

Engaging in unprotected sex with multiple partners increases the risk of contracting multiple strains of HIV, the virus that causes AIDS. Once inside a host, these strains can recombine into a new variant of the virus. One such recombinant variant observed in patients in Cuba appears to be much more aggressive than other known forms of HIV. Patients progress to AIDS within three years of infection – so rapidly that they may not even realise they were infected.

Published
16 February 2015
From
KU Leuven press release
Small world: Study of HIV subtype’s global spread shows impacts of tourism, migration, policies

The subtype that comprises 5 percent of HIV-1 infections globally traveled from Africa to Thailand where it was identified in 1989. From there, it spread around the world. Thailand's popularity as a tourist destination, including sex tourism, is one of the reasons.

Published
23 January 2015
From
Science Speaks
Starting HIV treatment early and then interrupting is no better than delaying it

A French study that looked at the total amount of time since infection that people with HIV have spent with a detectable viral load has found that,

Published
22 January 2015
By
Gus Cairns
Elite controllers may pay a high price for their low viral load

About one in 200 people with HIV maintains an undetectable viral load and high CD4 counts without having to take antiretroviral therapy (ART). These so-called ‘elite controllers’

Published
07 January 2015
By
Gus Cairns
HIV vaccines should avoid viral target cells, primate model study suggests

Vaccines designed to protect against HIV can backfire and lead to increased rates of infection. This unfortunate effect has been seen in more than one vaccine clinical trial. Scientists at Yerkes National Primate Research Center, Emory University, have newly published results that support a straightforward explanation for the backfire effect: vaccination may increase the number of immune cells that serve as viral targets.

Published
04 January 2015
From
EurekAlert
Could HIV make hearing worse?

A new study has found that low- and high-frequency hearing is poorer in adults with the human immunodeficiency virus, compared with adults who do not have the disease. Although unexpected, similar hearing loss has previously been observed to be more likely in adults with diabetes mellitus. "It is possible that both HIV infection and diabetes, being systemic diseases, could affect the neural function of the cochlea," the authors suggest.

Published
29 December 2014
From
Medical News Today
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