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Is It Safe to Alter the CCR5 Receptor? And How Will This Influence HIV Cure Studies?

The HIV cure effort suffered a potential setback this week, as researchers reported an association between having two copies of the CCR5-∆32 mutation and shorter survival.

Published
11 June 2019
From
NEJM Journal Watch
Early antiretroviral treatment may preserve key immune responses to HIV

Investigators from the Ragon Institute of MGH, MIT and Harvard have found that instituting combination antiretroviral treatment at the earliest stages of HIV infection may allow the generation of functional CD8 'killer' T cells and preservation of the CD4 helper T cells that are the virus's primary target.

Published
23 May 2019
From
Eurekalert Inf Dis
Scientists Identify Factors That Make People Naturally Resistant to HIV

Studying key points on the HIV virus that are weak to immune system attacks could lead to new treatments or HIV vaccines.

Published
07 May 2019
From
Smithsonian
In rare cases, immune system fails despite HIV suppression

Antiretroviral therapy (ART) is usually effective at suppressing HIV, allowing the immune system to recover by preventing the virus from destroying CD4+ T cells. Scientists have now identified a rare, paradoxical response to ART called extreme immune decline, or EXID. Five individuals evaluated at the NIAID experienced a significant decline in CD4+ T cell levels despite suppression of HIV below detectable levels for more than three years, according to a new report.

Published
23 April 2019
From
EurekAlert
New study reveals HIV’s vulnerabilities, opening up possibilities for complementary therapies

A new study’s findings suggest that we may have found a way to reveal the virus’s presence in human cells. In the study published Wednesday in Cell & Host Microbe, scientists were able to identify a new shape of an essential HIV protein that allows the virus to gain entry into our cells. And it turns out that keeping this protein — known as Envelope — in this new shape might reveal vulnerabilities within the virus to make it visible to the immune system.

Published
11 April 2019
From
STAT
Your sexual partners can change your microbiome, finds a study in mice

The study also hints at a link between those microbiome changes and a person's immune system and susceptibility to infections like HIV.

Published
05 April 2019
From
STAT
Detectable HIV Despite Treatment? Clonal Expansion Could Be The Culprit

In a study of people with a low but detectable viral load despite adherence to treatment, infected cells were apparently cloning themselves.

Published
14 March 2019
From
Poz
HIV-Related Immune Activation May Predict Weight Gain and Exacerbate Complications, Especially in Women

HIV can cause persistent immune activation that contributes to an increased risk of complications such as heart disease and certain cancers. New NIAID-supported research presented today [March 6] at the Conference on Retroviruses and Opportunistic Infections in Seattle sheds light on the relationship between immune activation and weight gain.

Published
11 March 2019
From
HIV.gov
Has a second person with HIV been cured?

“This is a big deal,” says Sharon Lewin, who heads the Peter Doherty Institute for Infection and Immunity in Melbourne, Australia. “It tells us that Timothy Brown wasn’t a one-off.” Although the interventions that the two patients received could only be used on a tiny fraction of the 37 million HIV-infected people worldwide, their stories point to cure strategies that could be more widely applicable.

Published
06 March 2019
From
Science Magazine
Using anti-cancer immunotherapy to fight HIV

Researchers at the University of Montreal Hospital Research Centre (CRCHUM) have shown that immunotherapy treatments against cancer could reduce the amount of virus that persists in people on triple therapy. In a study published in the journal Nature Communications, they show, in the cells of people living with HIV, how these therapies reveal the virus - until now hidden in the hollows of infected cells - to the immune system.

Published
20 February 2019
From
Eurekalert Medicine & Health
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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.