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HIV infection prematurely ages humans by an average of 5 years

Thanks to combination antiretroviral therapy, many people with HIV can be expected to live decades after being infected. Yet doctors have observed that these patients often show signs of premature aging. Now a study published April 21 in Molecular Cell has applied a highly accurate biomarker to measure just how much HIV infection ages people at the biological level -- an average of almost 5 years.

Published
22 April 2016
From
Eurekalert Inf Dis
New research explains why HIV is not cleared by the immune system

Scientists have identified a human (host) protein that weakens the immune response to HIV and other viruses. The findings have important implications for improving HIV antiviral therapies, creating effective viral vaccines, and advance a new approach to treat cancer.

Published
15 April 2016
From
Science Daily
What Is Chronic Inflammation and Why Is It Such a Big Deal for People With HIV?

A primer on the harms of HIV-related chronic inflammation, what treatments are being researched and what you can do to reduce inflammation and improve your long-term health.

Published
06 April 2016
From
Poz
How HIV infection increases the risk of tuberculosis

A study published in PLOS Pathogens suggests that it is not a general weakening of the immune system by HIV that initially leads to loss of Mtb control, but rather that HIV is associated with a failure to prevent harmful immune responses. As HIV disease progresses, the weakening immune system's focus on antiviral responses leaves it largely defenseless against the Mtb pathogen.

Published
18 March 2016
From
HIV / AIDS News From Medical News Today
Bacteria, viruses in gut linked to severity of HIV infection

HIV infection also can lead to diseases affecting the intestines, with increased gastrointestinal (GI) inflammation, diarrhea and problems with nutrient absorption. The role of gut microbes in such issues is not completely understood, but now, in two studies led by researchers at Washington University School of Medicine in St. Louis, scientists have identified intestinal bacteria and viruses as possible sources of such inflammation and disease.

Published
11 March 2016
From
HIV / AIDS News From Medical News Today
HIV-infected vaginal cells do not transmit HIV if plasma viral load is undetectable, researchers find

A group of researchers have cleared up an important question about HIV transmission, in experiments on mice. Although HIV-infected CD4 cells persist in the vagina even on

Published
15 February 2016
By
Gus Cairns
Two cases of PrEP failure on solo tenofovir pose significant research questions

A report originally presented to the 2015 BHIVA conference last year details two cases where therapeutic levels of solo tenofovir unequivocally failed to prevent HIV infection in

Published
14 January 2016
By
Gus Cairns
Does low-level HIV viral load raise the risk of disease progression and co-morbidities?

People living with HIV who have a detectable but low viral load – in the range of 50 to 500 or 1000 copies/ml – may continue to

Published
09 November 2015
By
Liz Highleyman
Infection with multiple HIV-1 variants leads to poorer clinical outcomes

HIV-1 infection with multiple founder variants points to poorer clinical outcomes than infection with a single variant, according to a paper published today in Nature Medicine. In the study researchers analyzed large sample sets from two important HIV vaccine efficacy trials -- the Step HIV vaccine clinical trial (HVTN 502) and RV144, the landmark vaccine clinical trial conducted in Thailand -- to evaluate whether genetic characteristics of the founder viral populations could influence markers of clinical outcomes.

Published
01 September 2015
From
Eurekalert Inf Dis
The Low-Down on Inflammation from an HIV Doctor

Inflammation is the generic term for the body’s response to injury. During injury, the immune system—our body’s defense system—activates a complicated network of cells and chemical signals. Acute inflammation, immune activation that’s rapid and self-limited, is essential for healing. But chronic inflammation, immune activation that continues even after the initial injury is gone, is problematic. Chronic inflammation is like a volume control knob on a stereo being stuck—with the volume turned all the way up.

Published
24 August 2015
From
BETA blog
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