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HIV can spread early, evolve in patients' brains

HIV can genetically evolve and independently replicate in patients' brains early in the illness process, an analysis of cerebral spinal fluid has found. Prompt diagnosis and treatment with antiretroviral therapy should reduce the risk that the virus could find refuge and cause damage in the brain, where some medications are less effective -- potentially enabling it to re-emerge, even after it is suppressed in the periphery, say researchers.

Published
27 March 2015
From
Eurekalert Inf Dis
Inflammation and gut leakage remains elevated in people with HIV despite early antiretroviral treatment

Inflammatory changes and damage to the gut begin very soon after initial HIV infection, and may not return to normal even when people start antiretroviral therapy (ART)

Published
16 March 2015
By
Liz Highleyman
Does HIV make you fat? Study connects viral load with fat gains

HIV infection, or inflammatory changes associated with it, may be responsible for fat accumulation and body fat redistribution, rather than HIV drugs, the Conference on Retroviruses and

Published
06 March 2015
By
Gus Cairns
Inflammation Persists Despite Very Early HIV Treatment

Biomarkers of inflammation increase during acute HIV infection and remain elevated despite early suppressive antiretroviral therapy, according to a study presented at CROI 2015, in Seattle, Washington.

Published
27 February 2015
From
The Body Pro
Fast-replicating HIV strains drive inflammation and disease progression

The results confirmed the team's previous finding that the replicative capacity of the newly established virus drives how quickly infected individuals' levels of CD4 T cells declined. People infected with viruses with high replicative capacity had more signs of acute inflammation in the first few months of infection. Their T cells displayed more signs of "exhaustion," which sets the stage for faster disease progression.

Published
20 February 2015
From
Emory University press release
Researchers may have caught HIV becoming more virulent

A study from Cuba has generated wide media interest because researchers have identified a particular variety of the virus which is associated with rapid post-diagnosis falls in

Published
19 February 2015
By
Gus Cairns
Starting HIV treatment early and then interrupting is no better than delaying it

A French study that looked at the total amount of time since infection that people with HIV have spent with a detectable viral load has found that,

Published
22 January 2015
By
Gus Cairns
Elite controllers may pay a high price for their low viral load

About one in 200 people with HIV maintains an undetectable viral load and high CD4 counts without having to take antiretroviral therapy (ART). These so-called ‘elite controllers’

Published
07 January 2015
By
Gus Cairns
HIV vaccines should avoid viral target cells, primate model study suggests

Vaccines designed to protect against HIV can backfire and lead to increased rates of infection. This unfortunate effect has been seen in more than one vaccine clinical trial. Scientists at Yerkes National Primate Research Center, Emory University, have newly published results that support a straightforward explanation for the backfire effect: vaccination may increase the number of immune cells that serve as viral targets.

Published
04 January 2015
From
EurekAlert
Could HIV make hearing worse?

A new study has found that low- and high-frequency hearing is poorer in adults with the human immunodeficiency virus, compared with adults who do not have the disease. Although unexpected, similar hearing loss has previously been observed to be more likely in adults with diabetes mellitus. "It is possible that both HIV infection and diabetes, being systemic diseases, could affect the neural function of the cochlea," the authors suggest.

Published
29 December 2014
From
Medical News Today
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