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HIV RNA lingers in CSF through up to 10 years of suppressive ART

HIV RNA remained detectable at low levels in cerebrospinal fluid (CSF) of almost 20% of patients who had HIV RNA levels below 40 copies/mL for up to 10 years of antiretroviral therapy (ART). The investigators believe their finding indicates that the central nervous system (CNS) can be an HIV reservoir during suppressive ART.

Published
28 October 2014
From
International AIDS Society
Health Deficits Accumulate Faster With HIV Than Without in Older Adults

Health deficits from a list of 31 variables accumulated significantly faster over 4 years in older HIV-positive adults in Italy than in a comparison group from the general population [1]. Among people with 3 deficits at a baseline visit, 92% in the HIV cohort had a worse health deficit score 4 years later, compared with 55% in the general population.

Published
27 October 2014
From
NATAP
Cardiovascular Disease Risk Missed in Many HIV-Positive Veterans Despite Better Risk-Assessment Tool

A retrospective analysis using the 2013 American College of Cardiology/American Heart Association (ACC/AHA) Guidelines and Pooled Cohort Equations (PCEs) for acute myocardial infarction (AMI) and cardiovascular disease (CVD) risk found that the PCE scores were a much better predictor of 10-year CVD risk than the Framingham risk score in a cohort of more than 15,000 HIV-positive veterans on antiretroviral therapy, according to a presentation at ICAAC 2014, made by Henning Drechsler, M.D., of the University of Texas Southwestern Medical Center.

Published
22 October 2014
From
The Body
IDWeek 2014: Longer Use, Age, Low Body Weight Raise Risk of Tenofovir Kidney Problems

Abnormal kidney biomarkers are common but rarely progress to serious kidney dysfunction in HIV positive people taking tenofovir, and longer duration of use, older age, and having diabetes or high blood pressure raise the risk, researchers reported at IDWeek 2014 last week in Philadelphia. A related study found that people with low body weight experienced progressive kidney function decline while taking tenofovir.

Published
20 October 2014
From
HIVandhepatitis.com
Inflammatory markers associated with development of diabetes in people taking HIV therapy

Low-level elevations in important markers of systemic inflammation are associated with the development of type-2 diabetes in people taking antiretroviral therapy (ART), investigators report in the online edition

Published
20 October 2014
By
Michael Carter
IDWeek 2014: Efavirenz Not Linked to Suicide in Analysis of Insurance Records

The non-nucleoside reverse transcriptase inhibitor efavirenz (Sustiva, also in the Atripla single-tablet regimen) was not associated with a higher rate of suicidal thoughts or attempts in an analysis conducted by manufacturer Bristol-Myers Squibb (BMS), researchers reported at the 2014 IDWeek meeting last week in Philadelphia.

Published
16 October 2014
From
HIVandHepatitis.com
Tobacco use associated with increased risk of oral HPV-16 infection

Study participants who reported tobacco use or had higher levels of biomarkers of tobacco exposure had a higher prevalence of the sexually transmitted infection, oral human papillomavirus type 16, according to a study in the Oct. 8 JAMA, a theme issue on infectious disease. HPV-16 is the most common cancer-causing variety of HPV.

Published
08 October 2014
From
Eurekalert
Unusual immune cell needed to prevent oral thrush, researchers find

An unusual kind of immune cell in the tongue appears to play a pivotal role in the prevention of thrush, according to the researchers who discovered them. The findings might shed light on why people infected with HIV or who have other immune system impairments are more susceptible to the oral yeast infection.

Published
07 October 2014
From
Science Daily
Study of Meningitis Vaccine Effectiveness for HIV-Positive People Urged

At least one New York City man who was in a recent cluster of three men who had meningitis was previously vaccinated against the bacteria, but may have had a reduced immune response because he is HIV-positive.

Published
03 October 2014
From
Gay City News
Population-based evidence for the preventative efficacy of quadrivalent HPV in Australia

A recently published study claims to provide the first whole population analysis of the impact on genital warts of a national HPV vaccination programme – and this may be the best predictor of the longer-term, and more important, cancer prevention benefits to be seen in future years. The findings show a decline of 89.9% in admissions involving warts from 2006/7 to 2010/11 for girls aged 12-17 yrs, a decline of 72.7% for women aged 18-26, and a decline of 38% for men aged 18-14 (the indirect effect of female vaccination).

Published
01 October 2014
From
BMJ Group blogs

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