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Malaria
Follow-up study describes declining efficacy of malaria vaccine candidate over 4 years

Long-term follow-up of a phase II study from KEMRI-Wellcome Trust Research Programme and Oxford University researchers in Kenya shows that the efficacy of a malaria vaccine candidate, RTS,S, wanes over time and varies with exposure to the malaria parasite.

Published
17 hours ago
From
Eurekalert Inf Dis
Cardiovascular disease
HIV increases the risk of heart attack, even in people with a suppressed viral load

Infection with HIV is associated with an increased risk of heart attack, investigators from the United States report in the Journal of the American Medical Association Internal Medicine.

Published
19 March 2013
By
Michael Carter
Opportunistic infections
MRSA in the Groin of HIV Patients Ups Infection Risk

Colonization of methicillin-resistant Staphylococcus aureus (MRSA) in the groin area of HIV-infected adults increases risk for subsequent clinical infection, according to results of a prospective study carried out by the Centers for Disease Control and Prevention.

Published
14 March 2013
From
Medscape (requires registration)
HIV treatment in children
Lopinavir/ritonavir equivalent to nevirapine in Ugandan children

A ritonavir-boosted lopinavir (LPV/r)-based regimen achieved a comparable rate of virologic suppression when compared to a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen in HIV-infected Ugandan children at 48

Published
14 March 2013
By
Carole Leach-Lemens
Lipodystrophy
Health Canada rejects tesamorelin for lipodystrophy

After consideration of the NDS, Health Canada decided that the risks of tesamorelin outweighed its benefits under the proposed conditions of use.

Published
13 March 2013
From
Theratechnologies press release
Neurological and cognitive problems
Over 10% in Older HIV Group Fit Alzheimer's Biomarker Risk Profile

Slightly more than 10% of older Australian patients with well-controlled HIV infection had cerebrospinal fluid (CSF) marker profiles consistent with Alzheimer's disease--a risk prevalence more than 10 times higher than in the general population at the same age.

Published
13 March 2013
From
NATAP
Recreational drug use
Recreational cocaine use linked to conditions that cause heart attack

Recreational cocaine users may have higher blood pressure, stiffer arteries and thicker heart muscle walls than non-users -- all of which can cause a heart attack. The Australian study is the first to document some of these cardiovascular abnormalities in seemingly healthy cocaine users long after the immediate effects of cocaine have worn off.

Published
13 March 2013
From
Science Daily
Women
HIV and women over 50: 'I've had to make this journey almost entirely alone'

Anna's story – that of an older, heterosexual British woman who has contracted HIV – is unusual, but she is certainly not alone.

Published
12 March 2013
From
The Guardian
Side-effects
Long-term efavirenz linked to worse neurocognitive function in US CHARTER group

Long-term treatment with an efavirenz-based regimen correlated with worse neurocognitive function than did treatment with lopinavir/ritonavir, according to results of a retrospective case-control comparison within the US CHARTER cohort.

Published
07 March 2013
From
EATG / NATAP
Diabetes
Every year of statin therapy boosts diabetes risk 10% in US HIV cohort

Every year of treatment with lipid-lowering statins boosted the risk of diabetes 10% in members of the HIV Outpatient Study (HOPS). The results confirm an earlier finding of self-reported diabetes associated with statin use in a large general-population study of US postmenopausal women, but the impact of statins seemed more modest in the HOPS analysis.

Published
07 March 2013
From
EATG / NATAP
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