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2000-Fold Drop in Latent Reservoir Needed for 1 Year Without ART

About a 2000-fold reduction in the HIV reservoir in resting CD4 cells may be needed to let most people stop antiretroviral therapy (ART) for a single year without rebound, according to results of a modeling study. Predicted large variations in rebound times after ART stops mean close monitoring will be required for this strategy.

Published
21 hours ago
From
International AIDS Society
Zambia: PMTCT Real Life Story

The pain of living through the loss of three children was enough to discourage Constance Mudenda from ever contemplating parenting. When she was pregnant, her greatest desire was to have a child born free of HIV, and now she will continue to mentor her daughter to ensure she is protected from acquiring HIV.

Published
21 hours ago
From
Times of Zambia
How HIV co-opts gut bacteria to pose as a familiar infection

One of the most effective methods used by HIV to evade control is to hide from the immune system. B-cells are crucial for controlling new infections, producing specific antibodies to attack it, which coat the surface of infected cells and tag them for destruction. But according to a study from Duke Medicine, published in Cell Host & Microbe, when HIV enters and begins replicating in the gut, the reaction of B cells is ineffective because the virus is able to pose as a “good” bacterium. Its gp41 surface protein - which is displayed on the surface of infected cells - looks like surface proteins on the cells of friendly gut bacteria.

Published
21 hours ago
From
The Conversation UK
HIV superinfection associated with accelerated viral load increase but has no impact on clinical disease progression

HIV superinfection has no impact on clinical disease progression, investigators report in the online edition of AIDS. Superinfection was associated with accelerated viral load increase and had a

Published
19 August 2014
By
Michael Carter
'Shock and kill' approach cures mice of HIV in world first

A combination of four drugs can flush out HIV-infected cells from hidden reservoirs in the body and kill them with a boost to the immune system, according to research published in the journal Cell today.

Published
18 August 2014
From
The Conversation
CBT counselling significantly increases adherence among participants in HIV PrEP study

A support intervention based on cognitive behavioural therapy (CBT) significantly improved adherence among people enrolled in an HIV pre-exposure prophylaxis (PrEP) study, investigators report in the August 15

Published
15 August 2014
By
Michael Carter
AIDS 2014: Disappointing HIV Cure News Leads to New Questions

The fourth IAS Towards an HIV Cure symposium -- an initiative of the International AIDS Society -- took place July 19-20, prior to the 20th International AIDS Conference in Melbourne.

Published
15 August 2014
From
HIVandhepatitis.com
Drugs that flush out HIV may impair killer T cells, possibly hindering HIV eradication

Histone deacetylase (HDAC) inhibitors have shown promise in 'flushing out' HIV from latently infected cells, potentially exposing the reservoirs available for elimination by cytotoxic T lymphocytes (CTL), also called killer T cells. However, findings now suggest that treatment with HDAC inhibitors might suppress CTL activity and therefore compromise the 'kill' part of a two-pronged 'flush-and-kill' HIV eradication strategy.

Published
15 August 2014
From
Science Daily
Excellent outcomes among people starting HIV therapy at high CD4 counts in Uganda

People in Uganda starting antiretroviral therapy (ART) with higher CD4 counts can achieve excellent outcomes, investigators report in the online edition of AIDS. Asymptomatic adults who started therapy

Published
08 August 2014
By
Michael Carter
Non-adherence to medication threatens Cambodia’s zero AIDS deaths target

The Cambodian Government has committed to reaching zero AIDS-related deaths by 2020. But the number of deaths among people who are living with HIV continues to rise, despite the fact that antiretroviral treatment is more widely available. One reason for this is because some people living with HIV are missing follow-up hospital appointments and failing to adhere to antiretroviral treatment.

Published
07 August 2014
From
Key Correspondents
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